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Article
Open AccessThe positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus
Preclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies have used same-sex dyads exclusively, and the role of factors relate...
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Article
The effects of gonadal hormones on heroin Self-Administration in male gonadectomized rats
Previous studies have shown that gonadal hormones influence opioid self-administration in female rodents, but very few studies have examined these effects in male rodents.
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Article
Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia
Negative symptoms and cognitive deficits contribute strongly to disability in schizophrenia, and are resistant to existing medications. Recent drug development has targeted enhanced NMDA function by increasing...
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Article
Ectopic expression of cDNAs from larkspur (Consolida ajacis) for increased synthesis of gondoic acid (cis-11 eicosenoic acid) and its positional redistribution in seed triacylglycerol of Camelina sativa
A β-ketoacyl-ACP-synthase II (KAS2) like enzyme and a lysophosphatidic acid acyltransferase (LPAT2) from Consolida ajacis catalyze gondoic acid biosynthesis and incorporation into the sn-2 position of seed TAG in...
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Article
Modulation of heroin intake by ovarian hormones in gonadectomized and intact female rats
Heroin intake decreases during the proestrus phase of the estrous cycle in female rats. Circulating concentrations of both estradiol and progesterone peak during proestrus, and it is not known which of these h...
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Article
Open AccessA randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-d-aspartate receptor blockade in healthy veterans
The kynurenine pathway (KP) is a strategic metabolic system that combines regulation of neuronal excitability via glutamate receptor function and neuroinflammation via other KP metabolites. This pathway has gr...
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Article
Pathways of unauthorized fish introductions and types of management responses
Unauthorized introductions are an ongoing problem for fisheries managers. To understand reasons for the continued spread of nonnative fish species, the pathways of nonnative fish introductions were analyzed fr...
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Article
Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats
Preclinical studies consistently report that aerobic exercise decreases drug self-administration and other forms of drug-seeking behavior; however, relatively few studies have examined other types of physical ...
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Article
Exercise as a Prevention for Substance Use Disorder: a Review of Sex Differences and Neurobiological Mechanisms
This report provides an update on clinical and preclinical findings for the efficacy of exercise to prevent substance use disorder with a focus on recent evidence for sex differences and neurobiological mechan...
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Article
Exercise as a Sex-Specific Treatment for Substance Use Disorder
Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its ef...
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Article
Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents
Loxapine for inhalation is a drug-device combination product approved in adults for the acute treatment of agitation associated with schizophrenia or bipolar I disorder. The primary objective of this study was...
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Article
Identification of Crepenynic Acid in the Seed Oil of Atractylodes lancea and A. macrocephala
Atractylodes rhizome is widely used in traditional Chinese herbal medicine. Although the chemical composition of the root has been studied in detail, the oil content and fatty acid composition of the seeds of Atr...
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Article
Modeling the Impact of Social Contact on Substance Use
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Article
The effects of sex, estrous cycle, and social contact on cocaine and heroin self-administration in rats
Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in e...
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Article
A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression
Patients with anxious major depressive disorder (AMDD) have more severe symptoms and poorer treatment response than patients with non-AMDD. Increasing evidence implicates the endogenous opioid system in the pa...
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Article
Open AccessDedicated Industrial Oilseed Crops as Metabolic Engineering Platforms for Sustainable Industrial Feedstock Production
Feedstocks for industrial applications ranging from polymers to lubricants are largely derived from petroleum, a non-renewable resource. Vegetable oils with fatty acid structures and storage forms tailored for...
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Article
Apocynaceae Seed Lipids: Characterization and Occurrence of Isoricinoleic Acid and Triacylglycerol Estolides
Isoricinoleic acid (9-hydroxy-cis-12-octadecenoic acid; IR) is a potential renewable feedstock for the oleochemical industry, a precursor for the synthesis of antimicrobial compounds and a component of the seed o...
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Article
A simple model for pollen-parent fecundity distributions in bee-pollinated forage legume polycrosses
A simple Weibull distribution based empirical model that predicts pollen-parent fecundity distributions based on polycross size alone has been developed in outbred forage legume species for inc...
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Article
Ameliorating slice gaps in multislice magnetic resonance images: an interpolation scheme
Standard two-dimension (2D) magnetic resonance imaging (MRI) clinical acquisition protocols utilize orthogonal plane images which contain slice gaps (SG). The purpose of this work is to introduce a novel inte...
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Article
Identification and Distribution of Oxygenated Fatty Acids in Plantago Seed Lipids
Plant oils rich in oxygenated fatty acids (FAs) are of interest as renewable raw materials for industry. Previous studies reported unusual oxygenated FAs in the seed lipids of Plantago major and P. ovata. To dete...
