389 Result(s)

Article

Alteration of binding sites for [³H]P1075 and [³H]glibenclamide in renovascular hypertensive rat aorta

The alterations of the binding sites for ATP-sensitive K⁺ channel (K_ATP) openers and blockers in aortic strips were investigated in hypertensive rats.

Hua-mei He, Chao-liang Long, Le-zhi Zhang, Ai-ling Fu… in Acta Pharmacologica Sinica (2005)

Article

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) ...

** Yang, Camilo J Acosta, Guo-ai Si, Jun Zeng, Cui-yun Li… in BMC Public Health (2005)

Article

New chemolysis for urological calcium phosphate calculi – a study in vitro

Advances in techniques have left very few indications for open surgical extraction of urinary stones currently. These advances notwithstanding, the search continues for medical approaches to urinary stone mana...

Zhang **ang-bo, Wang Zhi-**, Duan Jian-min, Lu Jian-zhong, Ma Bao-liang in BMC Urology (2005)

Article

Fibrin(ogen)olytic character of FII_a isolated from Agkistrodon acutus venom

To investigate the fibrin(ogen)olytic character of FII_a isolated from Agkistrodon acutus venom in vitro and in vivo.

Yi-wen Wang, **u-xia Liang, Jia-shu Chen, Qi Chen… in Acta Pharmacologica Sinica (2005)

Article

Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo

To investigate the enhancing effects of chitosan with or without enhancers on nasal recombinant hirudin-2 (rHV2) delivery in vitro and in vivo, and to evaluate the ciliotoxicity of these formulations.

Yu-jie Zhang, Chang-hua Ma, Wan-liang Lu, Xuan Zhang… in Acta Pharmacologica Sinica (2005)

Article

Ca²⁺ sparks and Ca²⁺ glows in superior cervical ganglion neurons

Ca²⁺ release from the endoplasmic reticulum (ER) is an integral component of neuronal Ca²⁺ signaling. The present study is to investigate properties of local Ca²⁺ release events in superior cervical ganglion (SCG...

Li-jun Yao, Gang Wang, Kun-fu Ou-yang, Chao-liang Wei… in Acta Pharmacologica Sinica (2006)

Article

Changes in Glial Cell Line-derived Neurotrophic Factor Expression in the Rostral and Caudal Stumps of the Transected Adult Rat Spinal Cord

Limited information is available regarding the role of endogenous Glial cell line-derived neurotrophic factor (GDNF) in the spinal cord following transection injury. The present study investigated the possible...

Hao-Li Zhou, Hui-Juan Yang, Yong-Mei Li, Ying Wang, Ling Yan… in Neurochemical Research (2008)

Article

Protective effects of TREK-1 against oxidative injury induced by SNP and H₂O₂

TREK-1 (TWIK-related K⁺ channel-1) is a 2-pore-domain K⁺ channel subtype. The present study investigated the role of TREK-1 in cell death induced by oxidative stress.

Li-na Sun, Liao-liao Li, Zheng-bin Li, Ling Wang… in Acta Pharmacologica Sinica (2008)

Article

Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats

The present study aimed to explore the protective effect of endogenous sulfur dioxide (SO₂) in the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats.

Hong-fang **, Shu-xu Du, **a Zhao, Hong-ling Wei… in Acta Pharmacologica Sinica (2008)

Article

Changes in Glial Cell Line-derived Neurotrophic Factor Expression in the Rostral and Caudal Stumps of the Transected Adult Rat Spinal Cord

Hao-Li Zhou, Hui-Juan Yang, Yong-Mei Li, Ying Wang, Ling Yan… in Neurochemical Research (2008)

Article

The association between pulse pressure and vascular access thrombosis in chronic hemodialysis patients

Vascular access thrombosis (VAT) is a major cause of morbidity in chronic hemodialysis (HD) patients and is characterized by chronic inflammation. Pulse pressure (PP) is positively associated with chronic infl...

Che-Yi Chou, Jiung-Hsiun Liu, Huey-Liang Kuo, Yao-Lung Liu… in Hypertension Research (2009)

Article

Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway

Resistance to 5-fluorouracil (5-FU) is a major cause of chemotherapy failure in advanced hepatocellular carcinoma (HCC).Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, has a cruc...

Liang-qi Cao, **ao-li Wang, Qian Wang, ** Xue… in Acta Pharmacologica Sinica (2009)

Article

A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis

Chicken type II collagen (CCII) is a protein extracted from the cartilage of chicken breast and exhibits intriguing possibilities for the treatment of autoimmune diseases by inducing oral tolerance. A 24-week,...

Wei Wei, Ling-Ling Zhang, Jian-Hua Xu, Feng **ao… in Arthritis Research & Therapy (2009)

Article

Characterization of High-Fat, Diet-Induced, Non-alcoholic Steatohepatitis with Fibrosis in Rats

An ideal animal model is necessary for a clear understanding of the etiology, pathogenesis, and mechanisms of human non-alcoholic steatohepatitis (NASH) and for facilitating the design of effective therapy for...

Zheng-Jie Xu, Jian-Gao Fan, **ao-Dong Ding, Liang Qiao… in Digestive Diseases and Sciences (2010)

Article

The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice

Dendritic cells (DCs) are professional antigen presenting cells that initiate specific immune responses against tumor cells. Transcription factor RBP-J-mediated Notch signaling regulates DC genesis, but whethe...

Fan Feng, Yao-Chun Wang, **ng-Bin Hu, **ao-Wei Liu, Gang Ji… in Molecular Cancer (2010)

Article

Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...

Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh… in BMC Cancer (2010)

Article

Crossover of the three-dimensional topological insulator Bi₂Se₃ to the two-dimensional limit

The gapless surface states of topological insulators could enable quantitatively different types of electronic device. A study of the topological insulating Bi₂Se₃ thin films finds that a gap in these states open...

Yi Zhang, Ke He, Cui-Zu Chang, Can-Li Song, Li-Li Wang, ** Chen… in Nature Physics (2010)

Article

Erratum: Crossover of the three-dimensional topological insulator Bi₂Se₃ to the two-dimensional limit

Nature Physics 6, 584–588 (2010); published online 13 June 2010; corrected after print 12 August 2010. On the first page of the PDF and printed versions of this Letter originally published, the full list of au...

Yi Zhang, Ke He, Cui-Zu Chang, Can-Li Song, Li-Li Wang, ** Chen… in Nature Physics (2010)

Article

Effects of caesarean section on maternal health in low risk nulliparous women: a prospective matched cohort study in Shanghai, China

Rates of caesarean section are progressively increasing in many parts of the world. As a result of psychosocial factors there has been an increasing tendency for pregnant women without justifiable medical indi...

Bing-shun Wang, Li-feng Zhou, David Coulter, Hong Liang… in BMC Pregnancy and Childbirth (2010)

Article

Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1

To study the effects of 3-n-butylphthalide (NBP) on the TREK-1 channel expressed in Chinese hamster ovary (CHO) cells.

**n-cai Ji, Wan-hong Zhao, Dong-xu Cao, Qiao-qiao Shi… in Acta Pharmacologica Sinica (2011)