99 Result(s)

Article

Alteration of binding sites for [³H]P1075 and [³H]glibenclamide in renovascular hypertensive rat aorta

The alterations of the binding sites for ATP-sensitive K⁺ channel (K_ATP) openers and blockers in aortic strips were investigated in hypertensive rats.

Hua-mei He, Chao-liang Long, Le-zhi Zhang, Ai-ling Fu… in Acta Pharmacologica Sinica (2005)

Article

Fibrin(ogen)olytic character of FII_a isolated from Agkistrodon acutus venom

To investigate the fibrin(ogen)olytic character of FII_a isolated from Agkistrodon acutus venom in vitro and in vivo.

Yi-wen Wang, **u-xia Liang, Jia-shu Chen, Qi Chen… in Acta Pharmacologica Sinica (2005)

Article

Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo

To investigate the enhancing effects of chitosan with or without enhancers on nasal recombinant hirudin-2 (rHV2) delivery in vitro and in vivo, and to evaluate the ciliotoxicity of these formulations.

Yu-jie Zhang, Chang-hua Ma, Wan-liang Lu, Xuan Zhang… in Acta Pharmacologica Sinica (2005)

Article

Ca²⁺ sparks and Ca²⁺ glows in superior cervical ganglion neurons

Ca²⁺ release from the endoplasmic reticulum (ER) is an integral component of neuronal Ca²⁺ signaling. The present study is to investigate properties of local Ca²⁺ release events in superior cervical ganglion (SCG...

Li-jun Yao, Gang Wang, Kun-fu Ou-yang, Chao-liang Wei… in Acta Pharmacologica Sinica (2006)

Article

Changes in Glial Cell Line-derived Neurotrophic Factor Expression in the Rostral and Caudal Stumps of the Transected Adult Rat Spinal Cord

Limited information is available regarding the role of endogenous Glial cell line-derived neurotrophic factor (GDNF) in the spinal cord following transection injury. The present study investigated the possible...

Hao-Li Zhou, Hui-Juan Yang, Yong-Mei Li, Ying Wang, Ling Yan… in Neurochemical Research (2008)

Article

Protective effects of TREK-1 against oxidative injury induced by SNP and H₂O₂

TREK-1 (TWIK-related K⁺ channel-1) is a 2-pore-domain K⁺ channel subtype. The present study investigated the role of TREK-1 in cell death induced by oxidative stress.

Li-na Sun, Liao-liao Li, Zheng-bin Li, Ling Wang… in Acta Pharmacologica Sinica (2008)

Article

Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats

The present study aimed to explore the protective effect of endogenous sulfur dioxide (SO₂) in the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats.

Hong-fang **, Shu-xu Du, **a Zhao, Hong-ling Wei… in Acta Pharmacologica Sinica (2008)

Article

Changes in Glial Cell Line-derived Neurotrophic Factor Expression in the Rostral and Caudal Stumps of the Transected Adult Rat Spinal Cord

Hao-Li Zhou, Hui-Juan Yang, Yong-Mei Li, Ying Wang, Ling Yan… in Neurochemical Research (2008)

Article

Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway

Resistance to 5-fluorouracil (5-FU) is a major cause of chemotherapy failure in advanced hepatocellular carcinoma (HCC).Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, has a cruc...

Liang-qi Cao, **ao-li Wang, Qian Wang, ** Xue… in Acta Pharmacologica Sinica (2009)

Article

The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice

Dendritic cells (DCs) are professional antigen presenting cells that initiate specific immune responses against tumor cells. Transcription factor RBP-J-mediated Notch signaling regulates DC genesis, but whethe...

Fan Feng, Yao-Chun Wang, **ng-Bin Hu, **ao-Wei Liu, Gang Ji… in Molecular Cancer (2010)

Article

Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...

Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh… in BMC Cancer (2010)

Article

Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1

To study the effects of 3-n-butylphthalide (NBP) on the TREK-1 channel expressed in Chinese hamster ovary (CHO) cells.

**n-cai Ji, Wan-hong Zhao, Dong-xu Cao, Qiao-qiao Shi… in Acta Pharmacologica Sinica (2011)

Article

Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity

The serum-free medium from Japanese encephalitis virus (JEV) infected Baby Hamster Kidney-21 (BHK-21) cell cultures was analyzed by liquid chromatography tandem mass spectrometry (LC-MS) to identify host prote...

Yi-** Wu, Chung-Ming Chang, Chun-Yu Hung, Meng-Chieh Tsai… in Virology Journal (2011)

Article

An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma

Treatment failure for esophageal carcinoma is frequently due to lymph node metastasis and invasion to neighboring organs. The aim of the present study was to investigate invasion- and metastasis-related genes ...

Jian Pan, Yan-Fang Tao, Zhuan Zhou, Bang-rong Cao… in Journal of Translational Medicine (2011)

Article

A strategy for emergency treatment of Schistosoma japonicum-infested water

Schistosomiasis japonica, caused by contact with Schistosoma japonicum cercaria-infested water when washing, bathing or production, remains a major public-health concern in China. The purpose of the present study...

You-Sheng Liang, Wei Wang, Yun-Tian **ng, Hong-Jun Li, Yong-Liang Xu… in Parasites & Vectors (2011)

Article

The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function

To investigate the effects of iptakalim on endothelial dysfunction induced by insulin resistance (IR) and to determine whether iptakalim improved IR associated with hypertension in fructose-fed rats (FFRs) and...

Yu Wang, Fu-hu Zeng, Chao-liang Long, Zhi-yuan Pan… in Acta Pharmacologica Sinica (2011)

Article

ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer

Treatment failure for breast cancer is frequently due to lymph node metastasis and invasion to neighboring organs. The aim of the present study was to investigate invasion- and metastasis-related genes in brea...

Jian Pan, Li-Chao Sun, Yan-Fang Tao, Zhuan Zhou… in Journal of Translational Medicine (2011)

Article

Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats

The most frequent pain in patients with metastatic breast and prostate cancer is bone pain, which can be severe and difficult to treat. The mechanisms underlying this pain remain unclear. Here we investigated ...

**ao-Wei Wang, Shan Hu, Qi-Liang Mao-Ying, Qian Li, Chang-Jiang Yang… in Molecular Brain (2012)

Article

Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma

Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may p...

Zhao-lei Zeng, Wen-**g Wu, **g Yang, Zhen-jie Tang… in Journal of Translational Medicine (2012)

Article

Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines

The neuroinflammatory responses in the spinal cord following bone cancer development have been shown to play an important role in cancer-induced bone pain (CIBP). Lipoxins (LXs), endogenous lipoxygenase-derive...

Shan Hu, Qi-Liang Mao-Ying, Jun Wang, Zhi-Fu Wang… in Journal of Neuroinflammation (2012)