54 Result(s)
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**-hua Leng
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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with hereditary hemorrhagic telangiectasis (HHT). All available managem...
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Publisher Correction: Cyclolignan synthesis streamlined by enantioselective hydrogenation of tetrasubstituted olefins
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Cyclolignan synthesis streamlined by enantioselective hydrogenation of tetrasubstituted olefins
Natural products have long been valuable sources of inspiration for drug discovery. Unfortunately, the inherent limitations of direct semisynthetic derivatizations have become clear, and the need to overcome t...
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Open AccessIGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma
Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in embryonic develo...
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TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis
Excessive apoptosis of intestinal epithelial cell (IEC) is a crucial cause of disrupted epithelium homeostasis, leading to the pathogenesis of ulcerative colitis (UC). The regulation of Takeda G protein-couple...
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Open AccessA large deletion conferring pale green leaves of maize
The structural basis of chloroplast and the regulation of chloroplast biogenesis remain largely unknown in maize. Gene mutations in these pathways have been linked to the abnormal leaf color phenotype observed...
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Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice
Promotion of hepatic glycogen synthesis and inhibition of hepatic glucose production are effective strategies for controlling hyperglycemia in type 2 diabetes mellitus (T2DM), but agents with both properties w...
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Microstructure and mechanical properties of Cr films deposited with different peak powers by high-power impulse magnetron sputtering
For high-power impulse magnetron sputtering (HIPIMS), the peak power applied to the target is of great importance for regulating the ionization degree of the metal target and ion/atom flux ratio. In this work,...
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Open AccessMap** the spatial distribution of fossil geothermal manifestations and assessment of geothermal potential of the Tangyin rift, Southeast of Taihang Mountain in China
The spatial prediction of geothermal sites along the southeast side of Taihang Mountain in the Tangyin rift is a critical goal in the development of renewable energy resources in cities such as Hebi in Henan p...
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Open AccessOrgan-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice
Organ-specific metastatic context has not been incorporated into the clinical practice of guiding programmed death-(ligand) 1 [PD-(L)1] blockade, due to a lack of understanding of its predictive versus prognos...
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Open AccessClinical translation of patient-derived tumour organoids- bottlenecks and strategies
Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and precision medicine. The intrinsic ab...
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Open AccessUsefulness of estimated pulse wave velocity for identifying prevalent coronary heart disease: findings from a general Chinese population
Aortic stiffness and coronary heart disease (CHD) share a similar spectrum of risk factors; previous studies have identified the association between aortic stiffness and CHD. Recent studies have demonstrated e...
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Open AccessGlobal, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...
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Open AccessRegio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
The enantioselective construction of C–CF2R (R: alkyl or fluoroalkyl) bonds has attracted the attention of synthetic chemists because of the importance of chiral fluorinated compounds in life and materials scienc...
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Effectiveness and Safety of Acupoint Application of Guan **n Su He Pill (冠心苏合丸) for Patients with Chronic Stable Angina Pectoris: A Multi-Center, Randomized Controlled Trial
To assess the clinical effectiveness of acupoint application (AP) of Guan **n Su He Pill (冠心苏合丸, GXSHP) for patients with chronic stable angina pectoris (CSAP).
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SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
Suppression of excessive hepatic gluconeogenesis is an effective strategy for controlling hyperglycemia in type 2 diabetes (T2D). In the present study, we screened our compounds library to discover the active ...
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Estimation of mountain block recharge on the northern Tianshan Mountains using numerical modeling
Mountain block recharge (MBR), an important water resource, is a widespread process that recharges lowland aquifers. However, little is known about MBR due to the limited climatic and geologic data in mountain...
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Preventive therapeutic options for postoperative recurrence of ovarian endometrioma: gonadotropin-releasing hormone agonist with or without levonorgestrel intrauterine system insertion
Here, we compared endometrioma recurrence rates in patients who have undergone a laparoscopic cystectomy and treated with a gonadotropin-releasing hormone agonist (GnRHa) alone or a GnRHa combined with a levon...
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Abscisic acid modulates differential physiological and biochemical responses of roots, stems, and leaves in mung bean seedlings to cadmium stress
Experiments were conducted to determine how exogenous abscisic acid (ABA) mediates the tolerance of plants to cadmium (Cd) exposure. Cd stress strongly reduced all the growth parameters of mung bean seedlings....
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Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the selective vulnerability of specific neuronal populations, the molecular signatures of which are largely unknown. To identify and characterize selectively vulner...
