29 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessImpact of fellowship training for specialists on thyroidectomy outcomes of patients with thyroid cancer
We aimed to evaluate the impact of fellowship training (FT) for thyroid specialists on the outcomes of patients with thyroid cancer. We reviewed surgeries performed for thyroid cancer before (non-FT group) and...
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Article
Open AccessEffect of endoscopic therapy and drug therapy on prognosis and rebleeding in patients with esophagogastric variceal bleeding
Esophagogastric variceal bleeding (EVB) is one of the common digestive system emergencies with poor prognosis and high rate of rebleeding after treatment. To explore the effects of endoscopic therapy and drug ...
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Article
Open AccessStereoselectivity control in Rh-catalyzed β-OH elimination for chiral allene formation
Stereoselectivity control and understanding in the metal-catalyzed reactions are fundamental issues in catalysis. Here we report sterically controlled rhodium-catalyzed SN2’-type substitution reactions of optical...
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Article
Open AccessComprehensive characterization of TGFB1 across hematological malignancies
TGFB1, which encodes TGF-β1, a potent cytokine regulating varies cellular processes including immune responses. TGF-β1 plays context-dependent roles in cancers and is increasingly recognized as a therapeutic targ...
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Article
Open AccessHigh-throughput and high-accuracy single-cell RNA isoform analysis using PacBio circular consensus sequencing
Although long-read single-cell RNA isoform sequencing (scISO-Seq) can reveal alternative RNA splicing in individual cells, it suffers from a low read throughput. Here, we introduce HIT-scISOseq, a method that ...
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Article
Open AccessPrognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue
This study aimed to investigate the prognostic impact of lymphovascular and perineural invasions in patients with squamous cell carcinoma of the tongue who received surgery-based treatment at our institution b...
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Article
Open AccessPhysiological mechanism of exogenous brassinolide alleviating salt stress injury in rice seedlings
Brassinolide (BR) is a sterol compound, which can regulate plant seed germination, flowering, senescence, tropism, photosynthesis, stress resistance, and is closely related to other signaling molecules. This s...
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Article
Open AccessGenomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project
We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-genome sequencing (WGS) individuals and 5,841 high-density genoty** individuals, and identify 81.5 million SNPs and INDELs, ...
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Article
Open AccessEfficient assembly of nanopore reads via highly accurate and intact error correction
Long nanopore reads are advantageous in de novo genome assembly. However, nanopore reads usually have broad error distribution and high-error-rate subsequences. Existing error correction tools cannot correct n...
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Article
Open AccessShoot organogenesis and somatic embryogenesis from leaf and root explants of Scaevola sericea
An efficient regeneration system via shoot organogenesis and somatic embryogenesis from in vitro leaf and root explants was established for Scaevola sericea for the first time. The highest axillary shoot prolifer...
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Article
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a...
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Article
Open AccessA mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for geno...
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Article
Open AccessGenome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulati...
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Article
Open AccessTrends of Visual Impairment and Blindness in the Singapore Chinese Population over a Decade
We evaluated the prevalence of visual impairment (VI) and blindness among Chinese adults in the Singapore Chinese Eye Study (SCES, 2009–2011), and compared the trends with the Tanjong Pagar Survey, Singapore (...
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Article
Open AccessExome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation
Performance of a recently developed test for association between multivariate phenotypes and sets of genetic variants (MURAT) is demonstrated using measures of bone mineral density (BMD). By combining individu...
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Article
Open AccessUsing Delaunay triangulation and Voronoi tessellation to predict the toxicities of binary mixtures containing hormetic compound
Concentration addition (CA) was proposed as a reasonable default approach for the ecological risk assessment of chemical mixtures. However, CA cannot predict the toxicity of mixture at some effect zones if not...
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Article
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
P53-binding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for class switch recombination in B lymphocytes and for sensitizing BRCA1-deficient tumours to poly-ADP-...
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Article
Open AccessA combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples
Imputation using the 1000 Genomes haplotype reference panel has been widely adapted to estimate genotypes in genome wide association studies. To evaluate imputation quality with a relatively larger reference p...
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Article
Open AccessComprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis
We performed a meta analysis to assess the relationship of FCGRs polymorphisms with the risk of SLE. Thirty-five articles (including up to 5741 cases and 6530 controls) were recruited for meta-analysis. The st...
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Article
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants wit...
