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Article
Open AccessEffect of endoscopic therapy and drug therapy on prognosis and rebleeding in patients with esophagogastric variceal bleeding
Esophagogastric variceal bleeding (EVB) is one of the common digestive system emergencies with poor prognosis and high rate of rebleeding after treatment. To explore the effects of endoscopic therapy and drug ...
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Article
Open AccessEstablishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies
Recurrent or metastatic cervical cancer (r/m CC) often has poor prognosis owing to its limited treatment options. The development of novel therapeutic strategies has been hindered by the lack of preclinical mo...
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Article
Open AccessImatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers, best exemplified by loss-of-function mutations in genes encoding components of the TGF-β signaling pathway in col...
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Article
QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis
Activation of the pro-apoptotic genes by the p53 family is a critical step in induction of apoptosis. However, the molecular signaling underlying their suppression remains largely unknown. Here, we report a ge...
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Article
Correction: The application of CRISPR/Cas9 system in cervical carcinogenesis
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Article
Open AccessThe application of CRISPR/Cas9 system in cervical carcinogenesis
Integration of high-risk HPV genomes into cellular chromatin has been confirmed to promote cervical carcinogenesis, with HPV16 being the most prevalent high-risk type. Herein, we evaluated the therapeutic effe...
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Article
Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway
Hepatocellular carcinoma (HCC) is recognized as the most common malignancy of the liver in adults. Many human cancers have been associated with the oncogenic activation of the Wnt/β-catenin signaling pathway. ...
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Article
Open AccessEffects of a stepwise, local patient-specific early oral feeding schedule after gastric cancer surgery: a single-center retrospective study from China
Nowadays, early oral feeding after gastrectomy has been gradually accepted and applied in the clinical practice, but there is still no specific uniform feeding regimen available which works best for patients i...
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Article
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechan...
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Article
Open AccessMonocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury
Age-related macular degeneration (AMD), a leading contributor of vision loss, currently lacks comprehensive treatment. While AMD histopathology involves retinal pigment epithelium (RPE) injury associated with ...
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Article
Short-term outcomes of laparoscopic D2 lymphadenectomy with complete mesogastrium excision for advanced gastric cancer
D2 lymphadenectomy has been widely accepted as a standard procedure of surgical treatment for local advanced gastric cancer [1, 2]. However, neither the dissection boundary nor the extent of the excision for peri...
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Article
Open AccessProximal segmentation of the dorsal mesogastrium reveals new anatomical implications for laparoscopic surgery
Generally, the gold standard of radical surgery for gastrointestinal (GI) tumors is en bloc resection of primary lesions and their related tissues. For gastric cancer, the ideal surgical treatment should be D2 ra...
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Article
Preparation and H2S Gas-Sensing Performances of Coral-Like SnO2–CuO Nanocomposite
Nanocomposites composed of SnO2 and CuO were prepared by hydrothermal method. The microstructures of obtained SnO2–CuO powders were characterized by X-ray diffraction, scanning electron microscopy, transmission ...
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Article
Enhancing the luminescence of carbon dots by do** nitrogen element and its application in the detection of Fe(III)
Carbon dots (CDs) attract great interests from scientists for their low toxicity and biocompatibility properties and their important applications in the fields of photocatalysts, batteries, bio-images and supe...
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Article
Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis
The primary cilium originates from the mother centriole and participates in critical functions during organogenesis. Defects in cilia biogenesis or function lead to pleiotropic phenotypes. Mutations in centros...
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Article
A Novel Three-parameter Flow Cytometric Analysis for Cell Cycle
Objective: To set up a three-parameter method for cell cycle analysis by two-laser flow cytometer, which can detect two types of cyclin plus DNA content in one measurement, and that analyze unscheduled express...
