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Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice
In nature, both males and females engage in competitive aggressive interactions to resolve social conflicts, yet the behavioral principles guiding...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant...
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The Role of the Neural Exposome as a Novel Strategy to Identify and Mitigate Health Inequities in Alzheimer’s Disease and Related Dementias
With the continuous increase of the elderly population, there is an urgency to understand and develop relevant treatments for Alzheimer’s disease and...
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scMultiome analysis identifies a single caudal hindbrain compartment in the develo** zebrafish nervous system
BackgroundA key step in nervous system development involves the coordinated control of neural progenitor specification and positioning. A...
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs
The role of the striatum in motor control is commonly assumed to be mediated by the two striatal efferent pathways characterized by striatal...
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Potential Mechanisms Underlying COVID-19-Mediated Central and Peripheral Demyelination: Roles of the RAAS and ADAM-17
Demyelination is among the most conspicuous neurological sequelae of SARS-CoV-2 infection (COVID-19) in both the central (CNS) and peripheral (PNS)...
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Changes of brain functional network in Alzheimer’s disease and frontotemporal dementia: a graph-theoretic analysis
BackgroundAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are the two most common neurodegenerative dementias, presenting with similar...
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Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its progenitor cells, astrocytes,...
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Persistent vocal learning in an aging open-ended learner reflected in neural FoxP2 expression
BackgroundMost vocal learning species exhibit an early critical period during which their vocal control neural circuitry facilitates the acquisition...
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Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic pain. The ventrolateral orbital cortex (VLO) plays a...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...
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Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta
As a risk factor for Alzheimer’s disease (AD), studies have demonstrated that long-term high-fat diet (HFD) could accelerate the deposition of...
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Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease
Parkinsons disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and alpha-synuclein aggregation. This comprehensive...
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Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
BackgroundThe eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural...
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Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
BackgroundUnderstanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors to shed light on...
