The impact of transposable elements (TEs) on gene regulatory networks and how they are governed remain poorly understood. A new study identifies a role for LINE1, a specific subset of TEs, in the long-range regulation of gene expression, particularly during embryonic development.
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Acknowledgements
Work in the Wang laboratory is supported by NIH grants R01HG007175, U24ES026699, U01HG009391 and UM1DA058219.
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Liang, Y., Wang, T. LINE1 mediates long-range DNA interactions. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01824-5
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DOI: https://doi.org/10.1038/s41588-024-01824-5
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