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Article
Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease
Human genetic prion diseases (gPrDs) are directly associated with mutations and insertions in the PRNP (Prion Protein) gene. We collected and analyzed the data of 218 Chinese gPrD patients identified between Jan ...
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Article
Open AccessSedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial
The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated.
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Article
S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways
The S100 protein family genes play a crucial role in multiple stages of tumorigenesis and progression. Most of S100 genes are located at chromosome locus 1q21, which is a region frequently rearranged in cancer...
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Article
Open AccessCD36 deficiency ameliorates drug-induced acute liver injury in mice
Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocyte...
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Article
Clinical characteristics of re-hospitalized COVID-19 patients with recurrent positive SARS-CoV-2 RNA: a retrospective study
At present, it has been noticed that some patients recovered from COVID-19 present a recurrent positive RNA test of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) after being discharged from hosp...
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Article
Kriging-based reliability analysis considering predictive uncertainty reduction
Over the past decade, several acquisition functions have been proposed for kriging-based reliability analysis. Each of these acquisition functions can be used to identify an optimal sequence of samples to be i...
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Article
Modeling Study of Metallurgical Slag Foaming via Dimensional Analysis
A procedural model is urgently required for optimization of slag foaming in metallurgical processes. Through physical modeling following the similarity criterion of the Morton number (Mo), this paper investigates...
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Article
Fumarylacetoacetate hydrolase is required for fertility in rice
The rice OsFAH gene functions identically to that of Arabidopsis SSCD1 encoding FAH. Loss of OsFAH ...
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Article
Open AccessPsychological responses among nurses caring for patients with COVID-19: a comparative study in China
Frontline healthcare nurses devoted themselves to deal with the outbreak of COVID-19, saving many lives. However, they are under incredible unknown psychological pressures with a considerable risk of infection...
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Article
Open AccessTribological properties of polyimide composites reinforced with fibers rubbing against Al2O3
Reinforcing fillers are of great importance in tribological performance and tribofilm formation of polymeric composites. In this study, the tribological properties of aramid particle (AP) and short carbon fibe...
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Article
One-step correction strategy for BDS-2/BDS-3 satellite observation code bias and multipath delay
Global navigation satellite systems and positioning, navigation, and timing services, such as the newly developed BeiDou satellite system (BDS), require high-accuracy satellite observations. Satellite-induced ...
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Chapter and Conference Paper
Research on Source Detection and Its Performance Analysis in Sensor Array
In this paper, the application of information theory to describe the existing problem of signal source in sensor array is investigated in the presence of complex additive white Gaussian noise (CAWGN). Firstly,...
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Chapter and Conference Paper
Radar Target Detection Based on Information Theory
In this paper, the information theory method (ITM) is applied to radar detection system in the presence of complex additive white Gaussian noise (CAWGN). We introduce the target existence parameter into the ra...
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Article
Evaluation of the stability of vegetated slopes according to layout and temporal changes
Vegetation in slopes can effectively improve slope stability. However, it is difficult to estimate the effects of vegetation on slope stability because of variations in plant species and environmental conditio...
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Article
Effectively reducing the bioavailability and leachability of heavy metals in sediment and improving sediment properties with a low-cost composite
Heavy metal–contaminated sediment is a common environmental problem. In situ stabilization is an effective and low-cost method to remediate heavy metal–contaminated sediment. In this study, a red mud-based low...
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Article
Open AccessOPA1 and MICOS Regulate mitochondrial crista dynamics and formation
Mitochondrial cristae are the main site for oxidative phosphorylation, which is critical for cellular energy production. Upon different physiological or pathological stresses, mitochondrial cristae undergo rem...
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Article
Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
IP10, KC and M-CSF Are Remarkably Increased in the Brains from the Various Strains of Experimental Mice Infected with Different Scrapie Agents
Activation of inflammatory cells and upregulations of a number of cytokines in the central nervous system (CNS) of patients with prion diseases are frequently observed. To evaluate the potential changes of som...
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Article
Open AccessBody mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tu...
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Article
Liver biopsy for hepatoblastoma: a single institution’s experience
Hepatoblastoma diagnoses require liver biopsies. We aimed to investigate factors affecting the success of liver biopsy for hepatoblastoma diagnoses.
