407 Result(s)

Article

The mechanisms, regulations, and functions of histone lysine crotonylation

Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene expression, cell development, and disease treatment. In the pas...

**g-yi **e, Jie Ju, ** Zhou, Hao Chen, Shao-cong Wang, Kai Wang… in Cell Death Discovery (2024)

Article

Retraction Note: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway

**-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen… in Cell Death & Disease (2024)

Article

APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation

The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...

Dan Zhang, Qi-Qi Ni, Shu-Yang Wang, Wen-Feng He… in Cellular and Molecular Life Sciences (2024)

Article

Crosstalk between autophagy and metabolism: implications for cell survival in acute myeloid leukemia

Acute myeloid leukemia (AML), a prevalent form of leukemia in adults, is often characterized by low response rates to chemotherapy, high recurrence rates, and unfavorable prognosis. A critical barrier in manag...

Yongfeng Chen, Jia Chen, Zhenyou Zou, Linglong Xu, **g Li in Cell Death Discovery (2024)

Article

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including SB203580 and SB202190, induce cell death ...

Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen… in Cell Death & Disease (2024)

Article

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma

Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen da...

Yuyan Chen, Zhengyi Zhu, **ngyu Wu, Hui Li, Wenxian Guan… in Cell Death Discovery (2024)

Article

miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model

Alzheimer’s disease (AD), an age-related progressive neurodegenerative disorder, exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the accumulation of Amyloid-beta 42 (Aβ42...

Prajakta Deshpande, Chao-Yi Chen, Anuradha Venkatakrishnan Chimata… in Cell Death & Disease (2024)

Article

FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression

Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER stress leads to cell apoptosis. Despite increasing research in this area, the underlying molecular mechanisms rem...

**g Ji, Aixin **g, Yuanyuan Ding, **nhui Ma, Qilan Qian… in Cell Death & Disease (2024)

Article

TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer

ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα-mediated PANX1 cleavage was essential for ATP r...

Kevin Chih-Yang Huang, Shu-Fen Chiang, Pei-Chun Lin, Wei-Ze Hong… in Cell Death & Disease (2024)

Article

Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain

The nuclear loss and cytoplasmic accumulation of TDP-43 (TAR DNA/RNA binding protein 43) are pathological hallmarks of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous...

Longhong Zhu, Fuyu Deng, Dazhang Bai, Junqi Hou… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells

**n-Yue Xu, **ao-Tao He, Jia Wang, Xuan Li, Yu **a, Yi-Zhou Tan… in Cell Death & Disease (2023)

Article

Correction: In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Li Li, Tao **ng, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, **g Zhao… in Cell Death Discovery (2023)

Article

Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis

COVID-19 has spread all over the world which poses a serious threat to social economic development and public health. Despite enormous progress has been made in the prevention and treatment of COVID-19, the sp...

Zhao-jun Chen, Jie **ao, Hai-hua Chen in Biochemical Genetics (2023)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

The oral bacterial microbiota facilitates the stratification for ulcerative colitis patients with oral ulcers

Clinically, a large part of inflammatory bowel disease (IBD) patients is complicated by oral lesions. Although previous studies proved oral microbial dysbiosis in IBD patients, the bacterial community in the g...

Jun Xu, Yu Zhang, **ao-Hui Fang, Yun Liu… in Annals of Clinical Microbiology and Antimi… (2023)

Article

NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Hippocampal neuronal damage may induce cognitive impairment. Neurotrophic tyrosine kinase receptor 1 (NTRK1) reportedly regulates neuronal damage, although the underlying mechanism remains unclear. The present...

Kai Yang, Jue Wu, Shang Li, Shan Wang, **g Zhang, Yi-peng Wang… in Cell Death Discovery (2023)

Article

Loss of fragile WWOX gene leads to senescence escape and genome instability

Induction of DNA damage response (DDR) to ensure accurate duplication of genetic information is crucial for maintaining genome integrity during DNA replication. Cellular senescence is a DDR mechanism that prev...

Hui-Ching Cheng, Po-Hsien Huang, Feng-Jie Lai… in Cellular and Molecular Life Sciences (2023)

Article

Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling

We here tested the potential activity and the underlying mechanisms of neuroligin-3 (NLGN3) against ischemia-reperfusion-induced neuronal cell injury. In SH-SY5Y neuronal cells and primary murine cortical neur...

Zhi-guo Chen, **n Shi, **an-xian Zhang, Fang-Fang Yang, Ke-ran Li… in Cell Death & Disease (2023)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)

PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma...

Huei-Jen Chen, Yi-An Cheng, Yu-Tung Chen, Chia-Ching Li… in Cancer Nanotechnology (2023)