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Article
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome
Glioblastoma (GBM) is the most common malignant tumor in the brain with temozolomide (TMZ) as the only approved chemotherapy agent. GBM is characterized by susceptibility to radiation and chemotherapy resistan...
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Article
Millisecond dynamics of colloidal suspension studied by X-ray photon correlation spectroscopy at the Shanghai Synchrotron Radiation Facility
X-ray photon correlation spectroscopy (XPCS) has emerged as a powerful tool for probing the nanoscale dynamics of soft condensed matter and strongly correlated materials owing to its high spatial resolution an...
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Article
An efficient extended IHB method for non-linear dynamic analysis with multi-frequency harmonic excitations using an auto adapted truncation technique
Demand on the analysis of a nonlinear system under multi-frequency harmonic excitations is commonly encountered in an engineering field, which requires a feasible analysis technique. The existing incremental h...
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Article
Tuning sodium wettability and pore tortuosity for superior sodium storage
Abundant FeS2 with high theoretical capacity is one of the promising anode candidates in sodium-ion batteries (SIBs), however, the uneven sodium deposition due to the poor interface compatibility and sluggish rea...
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Article
Unraveling intratumoral complexity in metastatic dermatofibrosarcoma protuberans through single-cell RNA sequencing analysis
Dermatofibrosarcoma protuberans (DFSP) stands as a rare and locally aggressive soft tissue tumor, characterized by intricated molecular alterations. The imperative to unravel the complexities of intratumor het...
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Article
Open AccessA magnetic resonance imaging-based decision-making tool for predicting complex anal fistulas healing in the early postoperative period
Magnetic resonance imaging (MRI) has excellent accuracy in diagnosing preoperative lesions before anal fistula surgery. However, MRI is not good in identifying early recurrent lesions and effective methods for...
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Article
Open AccessSingle-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for develo** effective treatments. Here, we utilized single-cell transcriptomic analysis and inte...
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Article
Open AccessMacrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression
Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as a...
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Article
Brain amyloid-β deposition associated functional connectivity changes of ultra-large structural scale in mild cognitive impairment
In preclinical Alzheimer’s disease, neuro-functional changes due to amyloid-β (Aβ) deposition are not synchronized in different brain lobes and subcortical nuclei. This study aimed to explore the correlation b...
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Article
Electroacupuncture in Treatment of Acute Gastrointestinal Injury in Patients with Severe Traumatic Brain Injury: A Multicenter Randomized Controlled Trial
To evaluate whether electroacupuncture (EA) would improve gastrointestinal function and clinical prognosis in patients with severe traumatic brain injury (TBI) complicocted by acute gastrointestinal injury (AGI).
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Article
Open AccessThe downregulation of miR-509-3p expression by collagen type XI alpha 1-regulated hypermethylation facilitates cancer progression and chemoresistance via the DNA methyltransferase 1/Small ubiquitin-like modifier-3 axis in ovarian cancer cells
MicroRNAs are a group of small non-coding RNAs that are involved in development and diseases such as cancer. Previously, we demonstrated that miR-335 is crucial for preventing collagen type XI alpha 1 (COL11A1...
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Article
Open AccessLaser treatment for Cafe-au-lait Macules: a systematic review and meta-analysis
Nowadays, laser is the mainstay treatment for cafe-au-lait macules (CALMs), but no systematic review has been published to demonstrate the overall efficacy and it’s still controversial which type of laser is o...
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Article
Open AccessThe shock, the co**, the resilience: smartphone application use reveals Covid-19 lockdown effects on human behaviors
Human mobility restriction policies have been widely used to contain the coronavirus disease-19 (COVID-19). However, a critical question is how these policies affect individuals’ behavioral and psychological w...
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Article
On solutions for several systems of complex nonlinear partial differential equations with two variables
This article is devoted to describe the entire solutions of several systems of the first order nonlinear partial differential equations. By using the Nevanlinna theory and the Hadamard factorization theory of ...
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Article
Open AccessClinical characteristics of patients with prenatal hydronephrosis in early postnatal period: a single center retrospective study
The study aims to investigate the clinical characteristics of early postnatal period in children with prenatal hydronephrosis (HN) in our single center for 8 years.
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Article
Open AccessLZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway
LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unk...
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Article
Open AccessVitamin D receptor prevents tumour development by regulating the Wnt/β-catenin signalling pathway in human colorectal cancer
Colorectal cancer (CRC) is a common disease threatening human lives worldwide, and vitamin D receptor (VDR) contributes protective roles in this disease. However, the molecular mechanisms underlying VDR protec...
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Article
Open AccessSerum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia
Community-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to investigate new early biomarkers and potential mechanisms involved in d...
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Article
Innovative approach with harmonic modes and finite element modeling for the nonlinear dynamic analysis of a suspension bridge
The nonlinear characteristics of a general multiple degree-of-freedom suspension bridge under harmonic excitation are studied with an innovative approach consisting of the harmonic modes, the finite element mo...
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Article
Author Correction: Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle
