34 Result(s)
within
Tin Wee Tan
Life Sciences
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Article
Open AccessExtending Asia Pacific bioinformatics into new realms in the "-omics" era
The 2009 annual conference of the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation dating back to 1998, was organized as the 8th International Conference on Bioinformatics...
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Open AccessA proposed minimum skill set for university graduates to meet the informatics needs and challenges of the "-omics" era
The development of high throughput experimental technologies have given rise to the "-omics" era where terabyte-scale datasets for systems-level measurements of various cellular and molecular phenomena pose co...
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Open AccessA comprehensive assessment of N-terminal signal peptides prediction methods
Amino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved off upon the passenger protein reachi...
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Open AccessA multi-factor model for caspase degradome prediction
Caspases belong to a class of cysteine proteases which function as critical effectors in cellular processes such as apoptosis and inflammation by cleaving substrates immediately after unique tetrapeptide sites...
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Open AccessEmerging strengths in Asia Pacific bioinformatics
The 2008 annual conference of the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation set up in 1998, was organized as the 7th International Conference on Bioinformatics (InC...
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Open AccessBioinformatics research in the Asia Pacific: a 2007 update
We provide a 2007 update on the bioinformatics research in the Asia-Pacific from the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation set up in 1998. From 2002, APBioNe...
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Open AccessRule-based knowledge aggregation for large-scale protein sequence analysis of influenza A viruses
The explosive growth of biological data provides opportunities for new statistical and comparative analyses of large information sets, such as alignments comprising tens of thousands of sequences. In such stud...
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Open AccessIdentification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis
The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying a...
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Open AccessEstablishing bioinformatics research in the Asia Pacific
In 1998, the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation was set up to champion the advancement of bioinformatics in the Asia Pacific. By 2002, APBioNet was able t...
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Open AccessPrediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris
Pemphigus vulgaris (PV) is a severe autoimmune blistering skin disorder that is strongly associated with major histocompatibility complex class II alleles DRB1*0402 and DQB1*0503. The target antigen of PV, des...
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Open AccessSVM-based prediction of caspase substrate cleavage sites
Caspases belong to a class of cysteine proteases which function as critical effectors in apoptosis and inflammation by cleaving substrates immediately after unique sites. Prediction of such cleavage sites will...
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Open AccessLarge-scale analysis of antigenic diversity of T-cell epitopes in dengue virus
Antigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antig...
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Open AccessSPdb – a signal peptide database
The signal peptide plays an important role in protein targeting and protein translocation in both prokaryotic and eukaryotic cells. This transient, short peptide sequence functions like a postal address on an ...
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Open AccessDEDB: a database of Drosophila melanogaster exons in splicing graph form
A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing. We have capitalized on this by constructing a dat...
