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Open AccessPI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher ag...
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Generalization bounds for learning under graph-dependence: a survey
Traditional statistical learning theory relies on the assumption that data are identically and independently distributed (i.i.d.). However, this assumption often does not hold in many real-life applications. I...
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Open AccessNotoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...
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Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome
Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous studies have shown that vagus nerve stimulation (VNS) exerts neuroprotection in ischem...
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Hole inhibition mechanisms of Mg/steel lap joint by pinless friction stir spot welding
Pinless friction stir spot welding (P-FSSW) was performed to manufacture Mg/steel lap joints. Orthogonal tests for P-FSSW of Mg/steel were investigated, and the main factors affecting the properties of Mg/stee...
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Open AccessLMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study
Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the suscepti...
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Influence of Heat-setting Temperature on the Microporous Structure and Properties of PP/HDPE Bilayer Microporous Membranes
Due to the mechanical stability of PP layer, the PP/HDPE double-layer microporous membrane could be prepared at a higher heat-setting temperature than that of PE monolayer membrane. In this work, the effects o...
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Open AccessA new strategy for fabricating low haze p-type CuI film
As an intrinsic p-type transparent conductor with a wide band gap of 3.1 eV, γ-CuI full of potential has gradually attracted the attention of researchers. However, γ-CuI films deposited by various techniques g...
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Open AccessIntegration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes
Horizontal gene transfer (HGT) events have rarely been reported in gymnosperms. Gnetum is a gymnosperm genus comprising 25‒35 species sympatric with angiosperms in West African, South American, and Southeast Asia...
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Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy
As a renewable, biocompatible, biodegradable soft material, chitin hydrogels have better advantages in stability, antibacterial activity, antifouling, cost, immunogenicity, and so on than most polymer hydrogel...
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ASO Visual Abstract: A Novel Classification System of Renal Hilar Tumors for Surgical Guidance: Technique, Outcome, and Safety
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Open AccessExploring the mediating role of calcium homeostasis in the association between diabetes mellitus, glycemic traits, and vascular and valvular calcifications: a comprehensive Mendelian randomization analysis
The interplay between diabetes mellitus (DM), glycemic traits, and vascular and valvular calcifications is intricate and multifactorial. Exploring potential mediators may illuminate underlying pathways and ide...
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Open AccessCognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have...
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Open AccessPathogenic mechanisms of cardiovascular damage in COVID-19
COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since the outbreak in December 2019, it has caused an unprecedented world pandemic, leading to a...
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Preparation of bifunctional electrocatalyst by recycling heavy metal ions from wastewater using EDTAD-functionalized MOF as highly efficient adsorbent
The recovery and subsequent reuse of heavy metal ions from industrial wastewater are crucial for promoting sustainable development, but they also present significant challenges. In this article, ethylenediamin...
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Open AccessOrganic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome
Antibiotic resistance genes (ARGs) and metal(loid) resistance genes (MRGs) coexist in organic fertilized agroecosystems based on their correlations in abundance, yet evidence for the genetic linkage of ARG-MRG...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Paeoniflorin regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes
The adhesive properties of vitiligo melanocytes have decreased under oxidative stress., cytoskeleton proteins can control cell adhesion. Paeoniflorin (PF) was proved to resist hydrogen peroxide (H2O2)-induced oxi...
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Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial
Women with gestational diabetes mellitus (GDM) or obesity are vulnerable to impaired gestational cardiovascular health (CVH) and cardiovascular disease (CVD) in the future. It is unclear if prenatal vitamin D ...
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Shoot and Root Traits are Associated with Varying Soil Phosphorus Supply in Chinese Cabbage
Purpose: Phosphorus (P) is an essential nutrient for crop growth. P absorption efficiency was closely correlated with the variety of crop traits. It is currently unclear how vegetable crops may adapt to variou...
