145 Result(s)

Article

An Adaptive Elastic Multi-model Big Data Analysis and Information Extraction System

With the diverse applications to industry and domain-specific context, multi-source information extraction on semi-structured and unstructured data, as well as across data models, is becoming more common. Howe...

Qiang Yin, Jianhua Wang, Sheng Du, Jianquan Leng, **tao Li… in Data Science and Engineering (2022)

Article

Analysis of mutations in DNA damage repair pathway gene in Chinese patients with hepatocellular carcinoma

The incidence of hepatocellular carcinoma (HCC) has increased in these years. DNA damage repair (DDR) pathway is required in response to DNA damage Gene mutations in DDR pathway play an important role in diffe...

Jiarong Li, Nianfeng Li, Muhammad Salman Azhar, Ling Liu, Liheng Wang… in Scientific Reports (2022)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

IGF1 receptor-targeted black TiO₂ nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignant tumors with features of matrix barrier caused poor drug permeability, and susceptibility to drug resistance. Herein, a PDAC and its stro...

Kaiwei Xu, Lufei **, Liu Xu, Yuchao Zhu, Lu Hong… in Journal of Nanobiotechnology (2022)

Article

Retraction Note to: Screening and identification of gastric adenocarcinoma metastasis-related genes using cDNA microarray coupled to FDD-PCR

Jianhua Wang, Shishu Chen in Journal of Cancer Research and Clinical Oncology (2022)

Article

A model for genuineness detection in genetically and phenotypically similar maize variety seeds based on hyperspectral imaging and machine learning

Variety genuineness and purity are essential indices of maize seed quality that affect yield. However, detection methods for variety genuineness are time-consuming, expensive, require extensive training, or de...

Keling Tu, Shaozhe Wen, Ying Cheng, Yanan Xu, Tong Pan, Haonan Hou… in Plant Methods (2022)

Article

A new model based inflammatory index and tumor burden score (TBS) to predict the recurrence of hepatocellular carcinoma (HCC) after liver resection

To establish a model based on inflammation index and tumor burden score (TBS) to predict recurrence of hepatocellular carcinoma (HCC) after liver resection. A retrospective study was performed on 217 patients ...

Jianhua Wang, Zeguo Chen, Liheng Wang, Sijia Feng, Qixuan Qiu… in Scientific Reports (2022)

Article

C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Enteropathogenic Escherichia coli and Salmonella pullorum are two important groups of zoonotic pathogens. At present, the treatment of intestinal pathogenic bacteria infection mainly relies on antibiotics, which ...

Ting Li, Na Yang, Da Teng, Ruoyu Mao, Ya Hao, **umin Wang, Jianhua Wang in BMC Microbiology (2022)

Article

A novel bone cement injector augments Chinese osteoporotic lumbar pedicle screw channel: a biomechanical investigation

The study aimed to (1) create a series of pedicle injectors with different number of holes on the sheath especially for the Chinese elderly patients and (2) further investigate the effects of the injectors on ...

Suochao Fu, Yu Zhang, Fuzhi Ai, Jianhua Wang, Zenghui Wu… in BMC Musculoskeletal Disorders (2022)

Article

Coexisting CLT in PTC is an independent predictor of tumor aggressiveness for patients aged under 55: a retrospective analysis of 635 patients

The study was aimed at investigating the potential role of chronic lymphocytic thyroiditis (CLT) in papillary thyroid cancer (PTC) aggressiveness for patients aged below 55, as well as to figure out factors in...

Bing’e Ma, **yi Chen, Zheng** Zhao, **aoyang Yin, Qin Ji… in BMC Endocrine Disorders (2022)

Article

Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies

Coal dust particles (CDP), an inevitable by-product of coal mining for the environment, mainly causes coal workers’ pneumoconiosis (CWP). Long-term exposure to coal dust leads to a complex alternation of biolo...

Min Mu, Bing Li, Yuanjie Zou, Wenyang Wang, Hangbing Cao… in Particle and Fibre Toxicology (2022)

Article

Regulation mechanism of biomolecule interaction behaviors on the superlubricity of hydrophilic polymer coatings

Hydrophilic polymer coatings can improve the surface characteristics of artificial implants. However, because they are used in vivo, they inevitably come into contact with biomolecules that affect their interf...

Caixia Zhang, Junmin Chen, Mengmeng Liu, Yuhong Liu, Zhifeng Liu, Hongyan Chu… in Friction (2022)

Article

Evaluating effect of metallic ions on aggregation behavior of β-amyloid peptides by atomic force microscope and surface-enhanced Raman Scattering

Excessive aggregation of β-amyloid peptides (Aβ) is regarded as the hallmark of Alzheimer’s disease. Exploring the underlying mechanism regulating Aβ aggregation remains challenging and investigating aggregati...

Yang **e, Lin Yu, Yuna Fu, Heng Sun, Jianhua Wang in BioMedical Engineering OnLine (2021)

Article

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women

Ovarian cancer survival varies considerably among patients, to which germline variation may also contribute in addition to mutational signatures. To identify genetic markers modulating ovarian cancer outcome, ...

Hongji Dai, **nlei Chu, Qian Liang, Mengyun Wang, Lian Li, Yao Zhou… in Cell Discovery (2021)

Article

LSGAN-AT: enhancing malware detector robustness against adversarial examples

Adversarial Malware Example (AME)-based adversarial training can effectively enhance the robustness of Machine Learning (ML)-based malware detectors against AME. AME quality is a key factor to the robustness e...

Jianhua Wang, **aolin Chang, Yixiang Wang, Ricardo J. Rodríguez… in Cybersecurity (2021)

Article

Transcriptomic profiling of the high-vigour maize (Zea mays L.) hybrid variety response to cold and drought stresses during seed germination

Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic...

Heqin Li, Haiwang Yue, Junliang **e, Junzhou Bu, Li Li, Xueying **n… in Scientific Reports (2021)

Article

Anterior reduction and C1-ring osteosynthesis with Jefferson-fracture reduction plate (JeRP) via transoral approach for unstable atlas fractures

To introduce a novel transoral instrumentation in the treatment of unstable fractures of the atlas.

Qiang Tu, Hu Chen, Zhan Li, Yuyue Chen, Aihong Xu… in BMC Musculoskeletal Disorders (2021)

Article

Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression

Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at an advanced stage. The purpose of this study was to examine the expression of myosin heavy chain 11 (MYH11) in GC and mechanisms related.

Jianhua Wang, ** Xu, Yan** Hao, Tingting Yu, Limin Liu, Yan Song, Yan Li in BMC Cancer (2021)

Article

Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (Bs...

Lin Yu, Nan Huang, Liangpeng Ge, Heng Sun, Yuna Fu… in Journal of Biological Engineering (2021)

Article

Detailed analysis of recovery process of cranial nerve palsy after IMRT-based comprehensive treatment in nasopharyngeal carcinoma

Cranial nerve (CN) palsy due to cancer involvement has been considered as an unfavorable prognostic factor for patients with nasopharyngeal carcinoma (NPC). We assessed the role of IMRT based treatment on the ...

Jian Zang, Yan Li, Shanquan Luo, Jianhua Wang, Bingxin Hou, Min Yao… in Radiation Oncology (2021)