42 Result(s)
within
H.-J. Merker
English
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Article
Enzyme cytochemistry combined with electron microscopy, pharmacokinetics, and clinical chemistry for the evaluation of the effects of steady-state valproic acid concentrations on the mouse
A number of organs from adult female mice were investigated after continuous application of the anticonvulsant drug valproic acid (VPA) by enzyme cytochemistry, light and electron microscopy, pharmacokinetics ...
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Article
Ultrastructure and enzyme histochemistry of the marmoset yolk sac and embryonic intestinal epithelium
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Article
Ultrastructure and enzyme histochemistry of maternal blood vessels in the marmoset placenta
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Article
Development and properties of malignant lymphoma induced by magnesium deficiency in rats
Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration wa...
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Article
An improved method for the preparation of human fetal and adult hepatocytes
A method to prepare isolated hepatocytes from the small amounts of liver or liver fragments obtained from the human fetus following therapeutic abortion in early pregnancy is described. The hepatocytes have be...
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Chapter and Conference Paper
Drug-Induced Damage to the Embryo or Fetus
The exclusion of possible toxicologic hazards is still encumbered with the evaluation of three problems involving major difficulties: carcinogenicity, “teratogenicity,” and mutagenicity. In this paper we will ...
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Article
The influence of insulin, cAMP and the calcium ionophore X 537 A on the growth of the cartilage anlagen of limb buds in vitro
Limb buds of 11-day-old mouse embryos were cultured for 6 days with insulin, dibutyryl cAMP and X 537 A. The cartilage anlage was reduced by insulin and enlarged by dibutyryl cAMP and X 537 A. The effects are ...
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Article
Effect of the pentosanpolysulfate SP 54 on the collagen of embryonic limb buds cultured in vitro
After addition of SP 54 to limb buds from 11-day-old mouse embryos in tissue culture, collagen with an altered structure is produced.
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Article
The effect of d-penicillamine of the skeletal development of rat foetuses
Rats received 20, 50 or 100mg/animal d-penicillamine i. p. twice daily on days 15, 16, 17, 18 and 19 of gestation, i. e. a total dose of 200, 500 resp. 1000 mg/animal. At all dosages the number of fetal resorptio...
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Article
Induction of skeletal malformations in organ cultures of mouse limb buds
In einer Organkultur von Extremitätenknospen (Mäuse-Embryonen Tag 11) gelingt es bereits nach Gaben von 0,01 μg/ml Actinomycin-D in den ersten 24 h die Bildung der Knorpelanlagen von Scapula und Humerus zu unt...
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Article
Benzo(a)pyrene hydroxylase activity in the whole implantation site, decidua, placenta and fetal membranes of the rat
Treatment of pregnant rats with 40 mg benzo(a)pyrene (BP) per kg body weight p.o. 24 h prior to sacrifice results in an induction of BP hydroxylase activity in the whole implantation site, the decidua, the pla...
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Article
Effect of cyclophosphamide pretreatment of pregnant animals on the activity of nuclear DNA-dependent RNA-polymerases in different parts of rat embryos
On day 13+0 h of gestation rats received 10 mg/kg cyclophosphamide i.p. 3, 9, and 24 h after administration of the drug the activities of the DNA-dependent RNA polymerase reactions were measured in the whole e...
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Article
Growth kinetics of mammalian embryos during the stage of differentiation
In order to get insight into the synthesis rates occuring in mammalian embryos during the phase of differentiation, wet and dry weight as well as DNA-, RNA-, and nitrogen content of the whole implantation site...
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Article
Effect of benzo(α)pyrene treatment on the benzo(α)pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation
Pregnant rats were treated with an oral dose of 40.0 mg benzo(α) pyrene (BP) per kg body weight and were sacrificed 24 h later. Maternal liver, placenta, and fetus were assayed for BP-hydroxylase activity. The...
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Article
Studies on the teratogenic phase specificity of actinomycin D in the rat
In order to elucidate the phase specificity of the embryo-lethal and teratogenic action of actinomycin D (day 5–10 of gestation) rats received 3H-actinomycin D at different times of gestation. The distribution of...
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Chapter
The Effect of Prolonged Chloramphenicol and Oxytetracycline Application on Fetal Development
The effects on the embryo of antibiotics and other drugs may be studied using the epidemiological approach. Another method is to observe what happens on the tissue level. Chloramphenicol (CAP) and oxytetracycl...
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Article
Electron microscopic studies on the oocyte maturation in cultures of juvenile rat ovaries
After cultivation in a modified Trowell-system (organ ciilture) oocytes of 12- to 40-day-old rats were studied under the light and electron microscope. The cultivation period was 72 hrs. Egg cells from primary...
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Article
Variations in drug metabolism during mammalian development genetic aspects
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Article
Fine structural localization of aspartate carbamoyltransferase in rat liver
A new procedure for demonstrating aspartate carbamoyltransferase (carbamoyl phosphate: L aspartate carbamoyltransferase, E. C.2.1,3.2) is described. The method is based on precipitating the released orthophosp...
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Article
Electron microscopic demonstration of ornithine carbamoyltransferase in rat liver
A method for electron microscopic demonstration of ornithine carbamoyltransferase (carbamyl phosphate: L ornithine carbamoyltransferase; E.C. 2.1.3.3) is described. The enzyme determination is based on precipi...
