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  1. No Access

    Article

    Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection

    Atherosclerosis and its related clinical complications are the leading cause of death. MicroRNA (miR)-92a in the inflammatory endothelial dysfunction leads to atherosclerosis. Krüppel-like factor 2 (KLF2) is r...

    Chiu-Mei Lin, Bao-Wei Wang, Chun-Ming Pan, Wei-Jen Fang in European Journal of Nutrition (2021)

  2. No Access

    Article

    The role of hardiness in securities practitioners' web-based continuing learning: Internet self-efficacy as a mediator

    Due to the rapid changes in global economic environments, enterprises have to continually enhance their business competitiveness. To improve business, planning educational training has been regarded as a chann...

    Yun-Fang Tu, Chiu-Lin Lai, Gwo-Jen Hwang in Educational Technology Research and Develo… (2021)

  3. Article

    Open Access

    Agricultural management and cultivation period alter soil enzymatic activity and bacterial diversity in litchi (Litchi chinensis Sonn.) orchards

    Agricultural management and temporal change including climate conditions and soil properties can result in the alteration of soil enzymatic activity and bacterial community, respectively. Therefore, different ...

    Yu-Pei Chen, Chia-Fang Tsai, Asif Hameed, Yu-Jen Chang in Botanical Studies (2021)

  4. Article

    Open Access

    Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph

    Triaging and prioritising patients for RT-PCR test had been essential in the management of COVID-19 in resource-scarce countries. In this study, we applied machine learning (ML) to the task of detection of SAR...

    Richard Du, Efstratios D. Tsougenis, Joshua W. K. Ho in Scientific Reports (2021)

  5. Article

    Open Access

    To drain or not to drain: the association between residual intraperitoneal gas and post-laparoscopic shoulder pain for laparoscopic cholecystectomy

    Residual intra-peritoneal gas may be associated with post-laparoscopic shoulder pain (PLSP), which is a frequently and disturbance compliant after surgery. Herein, we aimed to examine whether expiring residual...

    Shun-Chin Yang, Kuang-Yi Chang, Ling-Fang Wei, Yi-Ming Shyr in Scientific Reports (2021)

  6. Article

    Open Access

    Agricultural management practices influence the soil enzyme activity and bacterial community structure in tea plantations

    The soil quality and health of the tea plantations are dependent on agriculture management practices, and long-term chemical fertilizer use is implicated in soil decline. Hence, several sustainable practices a...

    Yu-Pei Chen, Chia-Fang Tsai, P. D. Rekha, Sudeep D. Ghate in Botanical Studies (2021)

  7. Article

    Open Access

    Development and testing of the hemodialysis symptom distress scale (HSD-22) to identify the symptom cluster by using exploratory factor analysis

    Patients receiving hemodialysis (HD) often experience multiple symptoms concurrently and these symptoms may impact their quality of life. A valid and reliable tool is needed to assess the symptom distress of p...

    Mei-Chu Chen, Ya-Fang Ho, Chiu-Chu Lin, Chia-Chen Wu in BMC Nephrology (2021)

  8. Article

    Open Access

    Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes

    We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of 228 COPD patients were identified a...

    Yung-Che Chen, Ying-Huang Tsai, Chin-Chou Wang, Shih-Feng Liu in Scientific Reports (2021)

  9. Article

    Open Access

    Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death

    Few studies quantify a cascade of dynamic transitions on the detailed components of metabolic syndrome (MetS) and subsequent progressions to cardiovascular disease (CVD) and its death. A total of 47,495 subjec...

    Ting-Yu Lin, Kuo-Liong Chien, Yueh-Hsia Chiu, Pi-Chun Chuang in Scientific Reports (2021)

  10. No Access

    Article

    Caregiver burden and health-related quality of life among primary family caregivers of individuals with schizophrenia: a cross-sectional study

    This study aimed to examine correlates of caregiver burden and health-related quality of life (HRQoL) among primary family caregivers of individuals with schizophrenia in inpatient psychiatric rehabilitation f...

    Chiu-Yueh Hsiao, Huei-Lan Lu, Yun-Fang Tsai in Quality of Life Research (2020)

  11. Article

    Open Access

    Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients

    The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled criti...

    Chih-Chung Shiao, Yu-Hsing Chang, Ya-Fei Yang, En-Tzu Lin in Scientific Reports (2020)

  12. No Access

    Article

    Description of Azoarcus nasutitermitis sp. nov. and Azoarcus rhizosphaerae sp. nov., two nitrogen-fixing species isolated from termite nest and rhizosphere of Ficus religiosa

    A polyphasic taxonomic approach was used to characterise two presumably novel bacteria, designated strains CC-YHH838T and CC-YHH848T isolated from termite nest and rhizosphere of Ficus religiosa, respectively. Th...

    Shih-Yao Lin, Asif Hameed, Chia-Fang Tsai, Guan-Hua Huang in Antonie van Leeuwenhoek (2020)

  13. No Access

    Chapter and Conference Paper

    Fractional Fast Fourier Transform on Pricing Cruel Oil Options under Lévy Process

    In order to calibrate the complicated derivatives trading and options pricing efficiency, fractional fast Fourier transform was used to investigate the options pricing efficiency under Lévy process. The result...

    Ming Fang, Chiu-Lan Chang in Cyber Security Intelligence and Analytics (2020)

  14. No Access

    Chapter and Conference Paper

    Radial Basis Function Neural Network and Prediction of Exchange Rate

    This study aims to predict the exchange rat based on radial basis function neural network (RBFNN). Concerning the selected sample point, it only responds to the inputs of neighboring samples and hence has bett...

    Ming Fang, Chiu-Lan Chang in Big Data Analytics for Cyber-Physical System in Smart City (2020)

  15. Article

    Open Access

    A reporter mouse for non-invasive detection of toll-like receptor ligands induced acute phase responses

    The acute phase response (APR) is a systemic first-line defense against challenges including infection, trauma, stress, and neoplasia. Alteration of acute phase protein (APP) levels in plasma is the most impor...

    Chun-Fang Huang, Shang-Yi Chiu, Hung-Wen Huang, Bing-Ho Cheng in Scientific Reports (2019)

  16. Article

    Open Access

    A randomized feasibility study of the effect of ascorbic acid on post-angioplasty restenosis of hemodialysis vascular access (NCT03524846)

    Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty resten...

    Chung-Wei Yang, Chih-Cheng Wu, Chien-Ming Luo, Shao-Yuan Chuang in Scientific Reports (2019)

  17. Article

    Open Access

    Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor

    There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sig...

    Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin in BMC Cancer (2019)

  18. Article

    Open Access

    Quantile-based fecal hemoglobin concentration for assessing colorectal neoplasms with 1,263,717 Taiwanese screenees

    Although fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-...

    Szu-Min Peng, Han-Mo Chiu, Hsiao-Hsuan Jen in BMC Medical Informatics and Decision Making (2019)

  19. Article

    Open Access

    Multimedia-assisted instruction on pain assessment learning of new nurses: a quasi-experimental study

    Pain assessment and treatment are key factors affecting the quality and safety of care for patients and capabilities related to them are crucial for new nursing staff. Consequently, we developed a multimedia-a...

    Tsung-Lan Chu, Jeng Wang, Hui-Ling Lin, Hsiu-Fang Lee in BMC Medical Education (2019)

  20. Article

    Open Access

    Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese

    The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the assoc...

    Tzy-Haw Wu, Jean Ching-Yuan Fann, Sam Li-Sheng Chen in Scientific Reports (2018)

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