45 Result(s)

Reference Work Entry In depth

Thiazolidin

Bingliang Fang in Encyclopedia of Cancer (2017)

Living Reference Work Entry In depth

Thiazolidin

Bingliang Fang in Encyclopedia of Cancer

Article

α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation

Patients with glioblastomas, the most common primary tumors of the central nervous system, have poor prognoses because of uncontrolled tumor cell invasion and proliferation. β-Catenin plays an important role i...

Haitao Ji, Ji Wang, Bingliang Fang, Xuexun Fang, Zhimin Lu in Journal of Neuro-Oncology (2011)

Reference Work Entry In depth

Thiazolidin

Bingliang Fang in Encyclopedia of Cancer (2011)

Reference Work Entry In depth

Thiazolidin

Bingliang Fang in Encyclopedia of Cancer (2009)

Article

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

Proteasome inhibitors have emerged as promising anticancer therapeutic agents. Bortezomib (PS-341), a specific proteasome inhibitor, exhibits antitumor activity against a wide range of malignancies and has bee...

Hongbo Zhu, Lidong Zhang, Fengqin Dong, Wei Guo, Shuhong Wu, Fuminori Teraishi… in Oncogene (2005)

Article

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a potential anticancer agent. However, considerable numbers of cancer cells, especially some highly malignant tumors, are resi...

Lidong Zhang, Bingliang Fang in Cancer Gene Therapy (2005)

Article

Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter

Local and locoregional administration of adenovectors expressing the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene has been demonstrated to be useful in treating established tumors in anima...

Dietmar Jacob, John J Davis, Lidong Zhang, Hongbo Zhu… in Cancer Gene Therapy (2005)

Article

Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK

We recently found that a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol (2,3-DCPE) could induce apoptosis and downregulate Bcl-XL expression in various cancer cells. Here, we found that 2,3-DCPE...

Hongbo Zhu, Lidong Zhang, Shuhong Wu, Fuminori Teraishi, John J Davis… in Oncogene (2004)

Article

GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells

The utility of dominant acting proapoptotic molecules to induce cell death in cancer cells is being evaluated in preclinical studies and clinical trials. We recently developed a binary adenoviral expression sy...

Tsuyoshi Honda, Simona Coppola, Lina Ghibelli, Song H Cho… in Cancer Gene Therapy (2004)

Article

Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis

The p53 gene is the most frequently mutated gene in human cancers. Loss of functional p53 leads to impaired responses of cancer cells to apoptosis induction and to poor prognosis in patients with certain types of...

Jian Gu, Lidong Zhang, Stephen G Swisher, **song Liu, Jack A Roth… in Oncogene (2004)

Article

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

To examine the role of H-ras in the development of human ovarian cancer, we used small inhibitory RNA (siRNA) to silence its expression in human ovarian cancer cell lines and assessed the effects of its silencing...

Gong Yang, Jennifer Anne Thompson, Bingliang Fang, **song Liu in Oncogene (2003)

Article

Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells

We evaluated anti-tumor activity and toxic effect of an adenoviral vector expressing the GFP/TRAIL fusion gene from the hTERT promoter (designated Ad/gTRAIL) on human breast cancer cell lines and on normal hum...

Tongyu Lin, Xuefeng Huang, Jian Gu, Lidong Zhang, Jack A Roth, Momiao **ong… in Oncogene (2002)

Article

A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo

Using a binary adenoviral system, we recently showed that the human telomerase reverse transcriptase (hTERT) promoter induces tumor-specific Bax gene expression. However, the strong cytotoxicity of Bax and other ...

Jian Gu, Lidong Zhang, Xuefeng Huang, Tongyu Lin, Min Yin, Kai Xu, Lin Ji… in Oncogene (2002)

Article

Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences

Our previous studies showed that the urokinase-type plasminogen activator receptor (uPAR) and the p16 tumor suppressor gene play a significant role in glioma invasion. We expected that downregulation of uPAR a...

Yoshiaki Adachi, Nirmala Chandrasekar, Yoshiaki Kin, Sajani S Lakka… in Oncogene (2002)