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Article
Open AccessA novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma
The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein....
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Article
Comparison in structure and predicted function of epiphytic bacteria on Neopyropia yezoensis and Neopyropia katadae
The economic alga Neopyropia, which holds significant value in China for its edibility and economic potential, harbors diverse epiphytic bacteria on its surface. The epiphytic bacteria on Neopyropia yezoensis and...
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Article
Open AccessAbstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
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Article
Open AccessStabilizing the cold plasma-stimulated medium by regulating medium’s composition
Over past several years, the cold plasma-stimulated medium (PSM) has shown its remarkable anti-cancer capacity in par with the direct cold plasma irradiation on cancer cells or tumor tissues. Independent of th...
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Article
Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways
We have shown that rutaecarpine extracted from the dried fruit of Chinese herb Evodia rutaecarpa (Juss) Benth (Wu Zhu Yu) promotes glucose consumption and anti-inflammatory cytokine expression in insulin-resistan...
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Article
The comparison of sensitivity of motion sickness between retinal degeneration fast mice and normal mice
Recent studies report that a conflict between information from the visual system and vestibular system is one of the main reasons for induction of motion sickness (MS). We may be able to clarify the integratio...
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Chapter and Conference Paper
sGC-cGMP Signaling: Target for Anticancer Therapy
The biologic endogenous production of cGMP was reported in the 1960s and followed by the demonstration of guanylyl cyclase activity and the isoforms of soluble and membrane-bound guanylyl cyclases. During the ...
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Article
Open AccessGenetic silencing of sGC β1 in cancer: role of epigenetic regulation
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Article
Open AccessNO-cGMP signalling and cancer therapy
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Article
Open AccessTargeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter
The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT)...
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Article
Open AccessFresh look on old substances – new class of NO-independent regulators of soluble guanylyl cyclase activity and function
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Article
Ca2+ channel actions of the non-dihydropyridine Ca2+ channel antagonist Ro 40-5967 in vascular muscle cells cultured from dog coronary and saphenous arteries
We studied the membrane effects of (1S,2S)-2-(2-[[3-2(benzimidazolyl) propyllmethylamino]ethyl)-6-fluoro-1,2,3,4-tetrahydro-l-isopropyl-2-naphthyl-methoxy-acetate dihydrochloride, Ro 40-5967, a new non-dihydro...
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Article
Age-related changes in the response to vasoconstrictor and dilator agents in isolated beagle coronary arteries
Responses to vasoactive agents were compared in helical strips of coronary arteries isolated from beagles of 30 days, 3 months, 2 years and 12 years old. Serotonin contracted the arterial strips dose-dependent...
