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    Article

    GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells

    The utility of dominant acting proapoptotic molecules to induce cell death in cancer cells is being evaluated in preclinical studies and clinical trials. We recently developed a binary adenoviral expression sy...

    Tsuyoshi Honda, Simona Coppola, Lina Ghibelli, Song H Cho… in Cancer Gene Therapy (2004)

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    Chapter

    Apoptosis and Cancer

    Apoptotic pathways appear to have evolved along with the earliest metazoans. Homologs of human Bcl-2 and caspase family members have been identified in eukaryotes as ancient as the nematode Caenhorhabditis elegan...

    Sean L. O’Connor, Fermin Briones, Nikhil S. Chari, Song H. Cho… in Essentials of Apoptosis (2003)