68 Result(s)

Article

A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2

Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and s...

Dawn Aitken, Laura L. Laslett, Guoqi Cai, Catherine Hill… in BMC Musculoskeletal Disorders (2018)

Article

Arthritis diagnosis and symptoms are positively associated with specific physical job exposures in lower- and middle-income countries: cross-sectional results from the World Health Organization’s Study on global AGEing and adult health (SAGE)

In higher income countries, work-related squatting and heavy lifting have been associated with increased arthritis risk. Here, we address the paucity of data regarding associations between arthritis and work-r...

Sharon L. Brennan-Olsen, Svetlana Solovieva, Eira Viikari-Juntura… in BMC Public Health (2018)

Article

Increase in body weight over a two-year period is associated with an increase in midfoot pressure and foot pain

There is a well-recognised relationship between body weight, plantar pressures and foot pain, but the temporal association between these factors is unknown. The aim of this study was to investigate the relatio...

Tom P. Walsh, Paul A. Butterworth, Donna M. Urquhart… in Journal of Foot and Ankle Research (2017)

Article

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka… in Arthritis Research & Therapy (2017)

Article

Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study

Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...

Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2017)

Article

Is low-dose amitriptyline effective in the management of chronic low back pain? Study protocol for a randomised controlled trial

Low back pain is a major clinical and public health problem, with limited evidence-based treatments. Low-dose antidepressants are commonly used to treat pain in chronic low back pain. However, their efficacy i...

Donna M. Urquhart, Anita E. Wluka, Malcolm R. Sim, Maurits van Tulder… in Trials (2016)

Article

Lumbar disc degeneration is associated with modic change and high paraspinal fat content – a 3.0T magnetic resonance imaging study

Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: a multi-level study of Australian registry data

Associations between socioeconomic position (SEP) and the uptake of primary total shoulder arthroplasty (TSA) is not well understood in the Australian population, thus potentially limiting equitable allocation...

Sharon L. Brennan-Olsen, Richard S. Page, Stephen E. Lane… in BMC Musculoskeletal Disorders (2016)

Article

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Vertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Response to: ‘A dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine’—authors’ reply

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2016)

Article

Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial

Osteoarthritis (OA) is a major clinical and public health problem, with no current medications approved as having disease modifying effects. HMG-CoA reductase inhibitors, or “statins”, a drug class widely used...

Yuanyuan Wang, Andrew Tonkin, Graeme Jones, Catherine Hill, Changhai Ding… in Trials (2015)

Article

A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss

The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing so are unclear. This longitudinal study determined whether the size of the IPFP (maximum cro...

Andrew J. Teichtahl, Ema Wulidasari, Sharmayne R. E. Brady… in Arthritis Research & Therapy (2015)

Article

A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine

Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2015)

Article

Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences

Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whethe...

Anita E. Wluka, Andrew J. Teichtahl, Rheza Maulana… in Arthritis Research & Therapy (2015)

Article

The association between obesity and foot pain: metabolic, biomechanical or both?

Paul A Butterworth, Hylton B Menz, Donna M Urquhart… in Journal of Foot and Ankle Research (2015)

Article

Wolff’s law in action: a mechanism for early knee osteoarthritis

There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such ke...

Andrew J. Teichtahl, Anita E. Wluka, Pushpika Wijethilake… in Arthritis Research & Therapy (2015)

Article

Weight change following knee and hip joint arthroplasty–a six-month prospective study of adults with osteoarthritis

Inconsistent findings of weight change following total knee (TKA) and hip (THA) arthroplasty may largely be attributable to heterogeneous cohorts and varied definitions of weight loss. This study examined weig...

Andrew J Teichtahl, Emma Quirk, Paula Harding… in BMC Musculoskeletal Disorders (2015)

Article

Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability

Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations ...

Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2015)

Article

Bone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults

The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abn...

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka… in Arthritis Research & Therapy (2015)

Article

Early cartilage abnormalities at the hip are associated with obesity and body composition measures – a 3.0T MRI community-based study

Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. This study examines whether the body mass index (BMI) and body composition are associated with h...

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka… in Arthritis Research & Therapy (2015)