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Open AccessAssociation between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study
To examine whether metformin use was associated with knee cartilage volume loss over 4 years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.
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Article
Open AccessA protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2
Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and s...
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Article
Open AccessArthritis diagnosis and symptoms are positively associated with specific physical job exposures in lower- and middle-income countries: cross-sectional results from the World Health Organization’s Study on global AGEing and adult health (SAGE)
In higher income countries, work-related squatting and heavy lifting have been associated with increased arthritis risk. Here, we address the paucity of data regarding associations between arthritis and work-r...
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Article
Open AccessIncrease in body weight over a two-year period is associated with an increase in midfoot pressure and foot pain
There is a well-recognised relationship between body weight, plantar pressures and foot pain, but the temporal association between these factors is unknown. The aim of this study was to investigate the relatio...
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Open AccessAssociations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study
Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...
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Open AccessFat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study
Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...
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Article
Open AccessIs low-dose amitriptyline effective in the management of chronic low back pain? Study protocol for a randomised controlled trial
Low back pain is a major clinical and public health problem, with limited evidence-based treatments. Low-dose antidepressants are commonly used to treat pain in chronic low back pain. However, their efficacy i...
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Open AccessLumbar disc degeneration is associated with modic change and high paraspinal fat content – a 3.0T magnetic resonance imaging study
Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a ...
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Article
Open AccessFew geographic and socioeconomic variations exist in primary total shoulder arthroplasty: a multi-level study of Australian registry data
Associations between socioeconomic position (SEP) and the uptake of primary total shoulder arthroplasty (TSA) is not well understood in the Australian population, thus potentially limiting equitable allocation...
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Article
Open AccessModic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study
Vertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined ...
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Open AccessResponse to: ‘A dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine’—authors’ reply
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Open AccessDoes statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial
Osteoarthritis (OA) is a major clinical and public health problem, with no current medications approved as having disease modifying effects. HMG-CoA reductase inhibitors, or “statins”, a drug class widely used...
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Article
Open AccessA large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss
The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing so are unclear. This longitudinal study determined whether the size of the IPFP (maximum cro...
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Open AccessA Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine
Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between...
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Article
Open AccessBone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences
Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whethe...
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Open AccessThe association between obesity and foot pain: metabolic, biomechanical or both?
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Open AccessWolff’s law in action: a mechanism for early knee osteoarthritis
There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such ke...
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Article
Open AccessWeight change following knee and hip joint arthroplasty–a six-month prospective study of adults with osteoarthritis
Inconsistent findings of weight change following total knee (TKA) and hip (THA) arthroplasty may largely be attributable to heterogeneous cohorts and varied definitions of weight loss. This study examined weig...
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Article
Open AccessPhysical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability
Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations ...
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Article
Open AccessBone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults
The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abn...