57 Result(s)

Article

Meta-analysis of genome-wide association studies for personality

Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, ...

M H M de Moor, P T Costa, A Terracciano, R F Krueger, E J C de Geus… in Molecular Psychiatry (2012)

Article

Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms

A A E Vinkhuyzen, T Dumenil, L Ryan, S D Gordon, A K Henders… in Molecular Psychiatry (2011)

Article

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network initiative of the US Foundation for the National Insti...

P F Sullivan, E J C de Geus, G Willemsen, M R James, J H Smit… in Molecular Psychiatry (2009)

Article

Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults

E C Nelson, A Agrawal, M L Pergadia, M T Lynskey, A A Todorov… in Molecular Psychiatry (2009)

Article

Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background

The significant worldwide health burden introduced by tobacco smoking highlights the importance of studying the genetic determinants of smoking behavior and the key factor sustaining compulsive smoking, that i...

A Loukola, U Broms, H Maunu, E Widén, K Heikkilä, M Siivola… in The Pharmacogenomics Journal (2008)

Article

Genetic Time-series Analysis Identifies a Major QTL for in vivo Alcohol Metabolism not Predicted by in vitro Studies of Structural Protein Polymorphism at the ADH1B or ADH1C Loci

After ingestion of a standardized dose of ethanol, alcohol concentrations were assessed, over 3.5 hours from blood (six readings) and breath (10 readings) in a sample of 412 MZ and DZ twins who took part in an...

A. J. Birley, J. B. Whitfield, M. C. Neale, D. L. Duffy, A. C. Heath… in Behavior Genetics (2005)

Article

Perceived social support in a large community sample

The positive health and wellbeing effects of social support have been consistently demonstrated in the literature since the late 1970s. However, a better understanding of the effects of age and sex is required.

W. L. Coventry, N. A. Gillespie, A. C. Heath… in Social Psychiatry and Psychiatric Epidemio… (2004)

Article

Genetic and Social Determinants of Initiation and Age at Onset of Smoking in Australian Twins

Retrospective data on age at onset of smoking, reported by 3810 adult Australian twin pairs, were analyzed to determine the role of genetic and environmental factors in the onset of smoking. Results of nonmetr...

A. C. Heath, K. M. Kirk, J. M. Meyer, N. G. Martin in Behavior Genetics (1999)

Article

A Twin Study of Drinking and Smoking Onset and Latencies from First Use to Regular Use

The early onset of alcohol and tobacco use has been associated with increased risk for later substance abuse and dependence problems. This study investigated genetic and environmental influences on age at onse...

M. C. Stallings, J. K. Hewitt, T. Beresford, A. C. Heath, L. J. Eaves in Behavior Genetics (1999)

Article

Somatic distress as a distinct psychological dimension

Background: Somatoform disorders such as neurasthenia and chronic fatigue are characterized by a combination of prolonged fatigue and disabling neuropsychological and neuromuscular sympt...

N. Gillespie, K. M. Kirk, A. C. Heath… in Social Psychiatry and Psychiatric Epidemio… (1999)

Article

Distinguishing Population Stratification from Genuine Allelic Effects with Mx: Association of ADH2 with Alcohol Consumption

A universal problem in genetic association studies is to distinguish associations due to genuine effects of the locus under investigation, or linkage disequilibrium with a nearby locus that has a genuine effec...

M. C. Neale, S. S. Cherny, P. C. Sham, J. B. Whitfield, A. C. Heath… in Behavior Genetics (1999)

Article

Longitudinal Genetic Analysis of Menstrual Flow, Pain, and Limitation in a Sample of Australian Twins

Genetically informative longitudinal data about menstrual disorders allow us to address the extent to which the same genetic risk mechanisms are operating throughout the reproductive life cycle. We investigate...

S. A. Treloar, N. G. Martin, A. C. Heath in Behavior Genetics (1998)

Article

Logistic regression analysis of twin data: Estimation of parameters of the multifactorial liability-threshold model

We extend the DeFries-Fulker regression model for the analysis of quantitative twin data to cover binary traits and genetic dominance. In the proposed logistic regression model, the cotwin's trait status,C, is th...

P. C. Sham, E. E. Walters, M. C. Neale, A. C. Heath, C. J. MacLean… in Behavior Genetics (1994)

Article

A model system for analysis of family resemblance in extended kinships of twins

The “Virginia 30,000” comprise 29,698 subjects from the extended kinships of 5670 twin pairs. Over 80 unique correlations between relatives can be derived from these kinships, comprised of monozygotic (MZ) and...

K. R. Truett, L. J. Eaves, E. E. Walters, A. C. Heath, J. K. Hewitt… in Behavior Genetics (1994)

Article

Testing hypotheses about direction of causation using cross-sectional family data

We review the conditions under which cross-sectional family data (e.g., data on twin pairs or adoptees and their adoptive and biological relatives) are informative about direction of causation. When two correl...

A. C. Heath, R. C. Kessler, M. C. Neale, J. K. Hewitt, L. J. Eaves… in Behavior Genetics (1993)