897 Result(s)
within
Biomedicine, general
**ng Long
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Article
Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells
To investigate the effects of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, on the expression of the phosphatase and tensin homologue deleted on chromosome 10 gene (PTEN) a...
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Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines
Comparative proteomics provide a powerful approach in screening for alterations in protein levels and post-translational modifications that are associated with tumors. In the present study, we aimed to identif...
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Article
Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes
To study the effects of long-term, low-dose sex hormone replacement therapy (HRT) on the volume and biochemical changes of the hippocampus in postmenopausal women carrying apolipoprotein E (apoE) gene ɛ3 or ɛ4.
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Open AccessWNKs: protein kinases with a unique kinase domain
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion t...
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Open AccessRecruitment of young women to a trial of chlamydia screening – as easy as it sounds?
Recruiting to trials is complex and difficult. The Prevention of Pelvic Infection (POPI) trial aims to see if screening women for chlamydia and treating those found to be infected reduces the incidence of pelv...
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Article
Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells
Mesenchymal stem cells (MSC) are a promising candidate for cardiac replacement therapies. However, the majority of transplanted MSC are readily lost after transplantation because of poor blood supply, ischemia...
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Open AccessCoexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer
Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2...
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Article
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases
To characterize and compare the different biological behaviors of 2 novel human osteosarcoma cell lines, Zos and Zos-M, established respectively from the primary tumor and the skip metastasis of an osteosarcom...
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Article
Open AccessCollagen density promotes mammary tumor initiation and progression
Mammographically dense breast tissue is one of the greatest risk factors for develo** breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, ...
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Open AccessProteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference
Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in huma...
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Open AccessExpression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways
The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increas...
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Open AccessIn situ TEM measurements of the mechanical properties and behavior of WS2 nanotubes
The mechanical properties of individual WS2 nanotubes were investigated and directly related to their atomic structure details by in situ transmission electron microscope measurements. A brittle mode deformati...
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Open AccessEffects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells
RECK is a novel tumour suppressor gene that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumour invasion, angiogenesis and metastasis. In the present study, we investigated the effects of ep...
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Effective induction of high-titer antibodies by viral vector vaccines
A novel immunization strategy that involves prime-boost vaccination with a recombinant adenovirus-poxvirus vector can induce strong, antigen-specific antibody responses. Antibodies induced by this viral-vector...
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Open AccessIdentification of a novel CHEK2variant and assessment of its contribution to the risk of breast cancer in French Canadian women
BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an imp...
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Article
Analysis of synonymous codon usage and evolution of begomoviruses
Begomoviruses are single-stranded DNA viruses and cause severe diseases in major crop plants worldwide. Based on current genome sequence analyses, we found that synonymous codon usage variations in the protein...
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Open AccessIn silico analysis and verification of S100 gene expression in gastric cancer
The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...
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Article
Stimulation of Na+-Ca2+ exchange by purified antibody against alpha-2 repeat of Na+-Ca2+ exchanger in rat cardiomyocytes
The aim of the present study was to investigate the effect of the antibody against alpha-2 repeat on Na+-Ca2+ exchanger (NCX) current (INa/Ca). To evaluate the functional specificity of this antibody, its effects...
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Recombinant interferon-alpha2b poly(lactic-co-glycolic acid) microspheres: pharmacokinetics-pharmacodynamics study in rhesus monkeys following intramuscular administration
Investigation into pharmacokinetic-pharmacodynamic properties of inter-feron-alpha (IFN-α)2b-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (MS) in rhesus monkey primates.
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GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms
Gambogic acid (GA) is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses potent antitumor activity. GA3, a new GA derivative, has bee...
