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Article
Open AccessHumanin activates integrin αV–TGFβ axis and leads to glioblastoma progression
The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying intracranial glioblastoma progression. Our findings demonst...
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Article
Open AccessInhibition of mitochondrial phosphate carrier prevents high phosphate-induced superoxide generation and vascular calcification
Vascular calcification is a serious complication of hyperphosphatemia that causes cardiovascular morbidity and mortality. Previous studies have reported that plasmalemmal phosphate (Pi) transporters, such as P...
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Article
Open AccessInsulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca2+ signaling whose perturbation leads to proteinuria. However, the effects of insulin action on store-ope...
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Article
Open AccessSoluble αKlotho downregulates Orai1-mediated store-operated Ca2+ entry via PI3K-dependent signaling
αKlotho is a type 1 transmembrane anti-aging protein. αKlotho-deficient mice have premature aging phenotypes and an imbalance of ion homeostasis including Ca2+ and phosphate. Soluble αKlotho is known to regulate ...
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Article
Open AccessEpinephrine minimizes the use of bipolar coagulation and preserves ovarian reserve in laparoscopic ovarian cystectomy: a randomized controlled trial
We propose a novel method, the epinephrine compression method (Epi-pledget), as a hemostasis method for ovarian cystectomy. A total of 179 patients undergoing laparoscopic ovarian cystectomy with strip** wer...
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Article
Open AccessAngiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease
MYH9, a widely expressed gene encoding nonmuscle myosin heavy chain, is also expressed in podocytes and is associated with glomerular pathophysiology. However, the mechanisms underlying MYH9-related glomerular...
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Article
Open AccessOxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases...
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Article
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
Klotho is a membrane protein predominantly produced in the kidney that exerts some antiageing effects. Ageing is associated with an increased risk of heart failure; whether Klotho is cardioprotective is unknow...
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Article
Regulation of TRPV5 Single-Channel Activity by Intracellular pH
The transient receptor potential channel TRPV5 contributes to the apical entry pathway for transcellular calcium reabsorption in the kidney. Acid load causes hypercalciuria in animals and humans. We have previ...
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Article
Open AccessWNKs: protein kinases with a unique kinase domain
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion t...
