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Article
Open AccessChromosome-level genome assembly of the cottony cushion scale Icerya purchasi
The cottony cushion scale, Icerya purchasi, a polyphagous pest, poses a significant threat to the global citrus industry. The hermaphroditic self-fertilization observed in I. purchasi is an exceptionally rare rep...
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Open AccessCTR > 0.7 predicts the subgroup of lung adenocarcinomas ≤ 2 cm at risk of poor outcome treated by sublobar resection compared to lobar resection
A standard surgical procedure for patients with small early-stage lung adenocarcinomas remains unknown. Hence, we aim in this study to assess the clinical utility of the consolidation-to-tumor ratio (CTR) when...
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Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway
Anshen Shumai Decoction (ASSMD) is traditionally employed to manage coronary artery disease arrhythmias. Its protective efficacy against myocardial infarction remains to be elucidated. This investigation emplo...
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Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy
Precise force measurement is critical to probe biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect, as well as the detection of gravitational waves. Yet, despi...
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Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract
Cataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we found that the expression level of miR-204-5p was diminished in the len...
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Open AccessStudy of the mechanical properties and propagation mechanisms of non-coplanar and discontinuous joints via numerical simulation experiments
Non-coplanar and discontinuously jointed rock masses are more complex than coplanar and discontinuously jointed rock masses. The mechanical properties and propagation mechanisms of non-coplanar and discontinuo...
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Open AccessMinimally invasive surgeries for spontaneous hypertensive intracerebral hemorrhage (MISICH): a multicenter randomized controlled trial
Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical methods for treating ICH. Unfortunately, thus far, no specific surgical method has been...
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Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial
Our study aimed to explore the efficacy of Bifidobacterium breve 207-1 on specific neurotransmitters and hormones and the ability to regulate lifestyle behaviors in healthy adults.
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20-Deoxyingenol Activates Mitophagy Through TFEB and Promotes Functional Recovery After Spinal Cord Injury
Spinal cord injury (SCI) can lead to permanent paralysis and various motor, sensory and autonomic nervous system dysfunction. The complex pathophysiological processes limit the effectiveness of many clinical t...
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Open AccessRadiomics of pericoronary adipose tissue on computed tomography angiography predicts coronary heart disease in patients with type 2 diabetes mellitus
Diabetes is a common chronic metabolic disease. The progression of the disease promotes vascular inflammation and the formation of atherosclerosis, leading to cardiovascular disease. The coronary artery periva...
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Open AccessThe RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF21...
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Open AccessThe Mutual Regulatory Role of Ferroptosis and Immunotherapy in Anti-tumor Therapy
Ferroptosis is a form of cell death that is triggered by the presence of ferrous ions and is characterized by lipid peroxidation induced by these ions. The mechanism exhibits distinct morphological characteris...
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A Polynomial Approach for Thermoelastic Wave Propagation in Functionally Gradient Material Plates
Functionally gradient material (FGM) in service often experience temperature variations that can affect the propagation characteristics of guided waves. This investigation aims to study the propagation of ther...
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Investigation of the Causal Relationship Between Autoimmune Diseases and Premature Ovarian Insufficiency
POI is a multifactorial disease due to lack of estrogen resulting in symptoms such as insomnia, osteoporosis, and voiding disorders. For most women, fertility is affected. Autoimmune diseases are chronic disea...
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Open AccessThe impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
This study investigated whether the Combat compensation method can remove the variability of radiomic features extracted from different scanners, while also examining its impact on the subsequent predictive pe...
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Open AccessBreaking law of overburden rock and key mining technology for narrow coal pillar working face in isolated island
When conducting retreat mining in segmented coal pillars, the dynamic evolution of stress and overlying strata structure is more complex than conventional working faces due to the influence of adjacent working...
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Open AccessInflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy
Osteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced bone remodeling and a deteriorating immune microenvironment. ...
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Open AccessEnhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model
Polycystic Ovary Syndrome (PCOS) is a widespread endocrine disorder among women, characterized by symptoms like ovarian cysts, hormonal imbalance, and metabolic issues. This research evaluates the therapeutic ...
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AP-Net: a metallic surface defect detection approach with lightweight adaptive attention and enhanced feature pyramid
Surface defect detection is essential for ensuring the quality of metallic products. Many excellent surface defect detectors have been designed in recent years. Most detection methods achieve success by using ...
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Surviving the Pandemic: NGOs’ Strategies to Cope with COVID-19
Focusing on the challenges brought about by the devastating COVID-19 pandemic in China and the Chinese government’s increasingly stringent regulatory policies, this paper poses the following research questions...
