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Article
Open AccessHOXD3 targeted by miR-203a suppresses cell metastasis and angiogenesis through VEGFR in human hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC), one of the most common aggressive tumors worldwide has a relatively high mortality rate among malignant tumors. MicroRNAs (miRNAs), acting as tumor suppressors, are involved in ...
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Article
Open AccessEvaluation of animal-to-human and human-to-human transmission of influenza A (H7N9) virus in China, 2013–15
A novel avian-origin influenza A(H7N9) virus emerged in China in March 2013 and by 27 September 2017 a total of 1533 laboratory-confirmed cases have been reported. Occurrences of animal-to-human and human-to-h...
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Article
Open AccessTranscriptomic profiling of Alternaria longipes invasion in tobacco reveals pathogenesis regulated by AlHK1, a group III histidine kinase
Tobacco brown spot, caused by Alternaria species, is a devastating tobacco disease. To explore the role of a group III histidine kinase (AlHK1) on A. longipes pathogenesis, the invasion progress of A. longipes wa...
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Article
Open AccessTwo novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations we...
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Article
Open AccessSelective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box
In nature, proteins have evolved sophisticated cavities tailored for capturing target guests selectively among competitors of similar size, shape, and charge. The fundamental principles guiding the molecular r...
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Article
Open AccessLipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial
This study aimed to provide insights into the relationship between lipid levels and new-onset diabetes (NOD) in 14,864 Chinese hypertensive patients without diabetes (6056 men and 8808 women) aged 45–75 years ...
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Article
Open AccessUtilization of a Wheat660K SNP array-derived high-density genetic map for high-resolution map** of a major QTL for kernel number
In crop plants, a high-density genetic linkage map is essential for both genetic and genomic researches. The complexity and the large size of wheat genome have hampered the acquisition of a high-resolution gen...
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Article
Open AccessSerum glycopattern and Maackia amurensis lectin-II binding glycoproteins in autism spectrum disorder
The pathophysiology of autistic spectrum disorder (ASD) is not fully understood and there are no diagnostic or predictive biomarkers. Glycosylation modified as many as 70% of all human proteins can sensitively...
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Article
Open AccessEffects of drought on leaf carbon source and growth of European beech are modulated by soil type
Drought potentially affects carbon balance and growth of trees, but little is known to what extent soil plays a role in the trade-off between carbon gain and growth investment. In the present study, we analyze...
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Article
Open AccessAortic arch calcification and risk of cardiovascular or all-cause and mortality in dialysis patients: A meta-analysis
Studies on aortic arch calcification (AAC) and mortality risk in maintenance dialysis patients have yielded conflicting findings. We conducted this meta-analysis to investigate the association between the pres...
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Article
Open AccessSanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway
Sanguisorba officinalis L. radix is a widely used herb called DiYu (DY) in China and has an extensive range of bioactivities, including anti-cancer, anti-inflammatory, and anti-oxidative activities. However, ther...
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Article
Open AccessIdentification of novel serum peptide biomarkers for high-altitude adaptation: a comparative approach
We aimed to identify serum biomarkers for screening individuals who could adapt to high-altitude hypoxia at sea level. HHA (high-altitude hypoxia acclimated; n = 48) and HHI (high-altitude hypoxia illness; n = 48...
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Article
Open AccessTrait self-esteem and neural activities related to self-evaluation and social feedback
Self-esteem has been associated with neural responses to self-reflection and attitude toward social feedback but in different brain regions. The distinct associations might arise from different tasks or task-r...
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Article
Open AccessSynthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives
A series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS assay. The results indicated that ...
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Article
Open AccessLatency of auditory evoked potential monitoring the effects of general anesthetics on nerve fibers and synapses
Auditory evoked potential (AEP) is an effective index for the effects of general anesthetics. However, it’s unknown if AEP can differentiate the effects of general anesthetics on nerve fibers and synapses. Pre...
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Article
Open AccessHeralded Quantum Entanglement between Distant Matter Qubits
We propose a scheme to realize heralded quantum entanglement between two distant matter qubits using two Λ atom systems. Our proposal does not need any photon interference. We also present a general theory of ...
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Article
Open AccessRe-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses
Using RefSeq annotations, most disease/trait-associated genetic variants identified by genome-wide association studies (GWAS) appear to be located within intronic or intergenic regions, which makes it difficul...
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Article
Chirality-specific growth of single-walled carbon nanotubes on solid alloy catalysts
Single-walled carbon nanotubes of a single chirality can be produced with an abundance of more than 92 per cent when using tungsten-based bimetallic alloy nanocrystals as catalysts.
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Article
Open AccessDiameter-controlled growth of aligned single-walled carbon nanotubes on quartz using molecular nanoclusters as catalyst precursors
Molecular nanoclusters containing Fe and Mo atoms have been used as catalyst precursors for the growth of single-walled carbon nanotubes (SWNTs) on stable temperature (ST)-cut quartz substrates by chemical vap...
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Article
Open AccessDeposition of bio-mimicking graphene sheets with lotus leaf-like and cell-like structures on the nickel substrate
Bio-mimicking graphene films, deposited on textured nickel substrates, were synthesized by the following method: replicating the surface textures of the lotus leaf by polymer duplication, fabricating textured ...