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Article
Open AccessAn intelligent threshold selection method to improve orbital angular momentum-encoded quantum key distribution under turbulence
High-dimensional quantum key distribution (HD-QKD) encoded by orbital angular momentum (OAM) presents significant advantages in terms of information capacity. However, perturbations caused by free-space atmosp...
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Article
An Innovative Coupled Common-Node Discrete Element Method-Smoothed Particle Hydrodynamics Model Developed with LS-DYNA and Its Applications
In this study, a common-node DEM-SPH coupling model based on the shared node method is proposed, and a fluid–structure coupling method using the common-node discrete element method-smoothed particle hydrodynam...
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Article
Occurrence dynamics of ratoon stunting disease in various ecological sugarcane planting regions in Yunnan
Ratoon stunting disease (RSD) is a pervasive bacterial disease in the world, which seriously affects the yield and quality of sugarcane. To clarify the incidence of RSD in various ecological zones, different v...
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Article
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer’s disease mouse model by activating Nrf2 signaling pathway
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in elderly people and substantially affects patient quality of life. Oxidative stress is considered a ke...
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Article
Open AccessThe effect of illness perception on psychosocial adjustment of patients with breast cancer and their spouses: actor–partner independence model
With the increase in the prevalence rate and improvements in the survival of breast cancer patients, there is a growing interest in understanding the level of psychosocial adjustment in these patients. The stu...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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Article
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...
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Article
Open AccessSafety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study
The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 eld...
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Article
Observation of spectral lines in the exceptional GRB 221009A
As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A...
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Article
Open AccessMonocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer’s disease
Understanding the molecular mechanisms of Alzheimer’s disease (AD) has important clinical implications for guiding therapy. Impaired amyloid beta (Aβ) clearance is critical in the pathogenesis of sporadic AD, ...
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Article
Open AccessCanagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...
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Article
Open AccessSystematic investigation of the material basis, effectiveness and safety of Thesium chinense Turcz. and its preparation Bairui Granules against lung inflammation
Thesium chinense Turcz. (Named as Bai Rui Cao in Chinese) and its preparations (e.g., Bairui Granules) have been used to treat inflammatory diseases, such as acute mastitis, lobar pneumonia, tonsillitis, coronavi...
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Article
Azocalixarenes: a scaffold of universal excipients with high efficiency
Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, incl...
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Article
Differentiation of confluent hepatic fibrosis and infiltrative hepatocellular carcinoma on MR imaging
To identify reliable magnetic resonance imaging (MRI) features that can differentiate confluent fibrosis (CF) from infiltrative hepatocellular carcinoma (HCC).
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Article
Relationships between early life adversity and depressive symptoms in adolescents: a network analysis
Previous studies have demonstrated that depressive symptoms in adolescents were strongly associated with early life adversity (ELA). However, previous studies mainly considered the relationships between a sing...
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Article
Open AccessInvestigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response...
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Article
High dimensional proteomic map** of bone marrow immune characteristics in immune thrombocytopenia
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the sing...
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Article
Open AccessInterferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role...
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Article
Open AccessMulti-objective coyote optimization algorithm based on hybrid elite framework and Meta-Lamarckian learning strategy for optimal power flow problem
A multi-objective coyote optimization algorithm based on hybrid elite framework and Meta-Lamarckian learning strategy (MOCOA-ML) was proposed to solve the optimal power flow (OPF) problem. MOCOA-ML adds extern...
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Article
Open AccessDeficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion
The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...
