118 Result(s)
within
Science, multidisciplinary
**-Tian Tang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRegulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain
Mutations of X-linked gene Methyl CpG binding protein 2 (MECP2) are the major causes of Rett syndrome (RTT), a severe neurodevelopmental disorder. Duplications of MECP2-containing genomic segments lead to severe ...
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Article
Open AccessAccelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. How...
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Article
Open AccessThe population genetic structure of Corythucha ciliata (Say) (Hemiptera: Tingidae) provides insights into its distribution and invasiveness
Corythucha ciliata (Say), an invasive pest originating from North America, causes severe damage on sycamore trees. However, little is known about the population genetics and evolutionary ...
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Article
Open AccessMechano-regulated surface for manipulating liquid droplets
The effective transfer of tiny liquid droplets is vital for a number of processes such as chemical and biological microassays. Inspired by the tarsi of meniscus-climbing insects, which can climb menisci by def...
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Article
Open AccessNKG2D+CD4+ T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in S...
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Article
Open AccessPrognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors
Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and t...
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Open AccessExosomal microRNAs in giant panda (Ailuropoda melanoleuca) breast milk: potential maternal regulators for the development of newborn cubs
The physiological role of miRNAs is widely understood to include fine-tuning the post-transcriptional regulation of a wide array of biological processes. Extensive studies have indicated that exosomal miRNAs i...
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Open AccessValues of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases
Preoperative assessment of the cervical lymph node status is important in therapeutic schedule and further evaluations of prognosis for papillary thyroid carcinoma (PTC) patients. Our aim was to investigate th...
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Article
Open AccessComparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in China
There is currently a pandemic of pseudorabies virus (PRV) variant strains in China. Despite extensive research on PRV variant strains in the past two years, few studies have investigated PRV pathogenicity-rela...
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Open AccessPredictive models of minimal hepatic encephalopathy for cirrhotic patients based on large-scale brain intrinsic connectivity networks
We aimed to find the most representative connectivity patterns for minimal hepatic encephalopathy (MHE) using large-scale intrinsic connectivity networks (ICNs) and machine learning methods. Resting-state fMRI...
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Article
Open AccessCCK reduces the food intake mainly through CCK1R in Siberian sturgeon (Acipenser baerii Brandt)
To explore the effect of CCK on food intake in Siberian sturgeon, cck cDNA sequence of 1005 bp was obtained, and cck mRNA possessed the highest expression in brain. The expressions of cck were significantly incre...
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Article
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in non-homeostatic conditions by activating the emergency circuit respo...
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Article
Open AccessEffects of discrete dynamic-conductivity fractures on the transient pressure of a vertical well in a closed rectangular reservoir
With the extraction of hydrocarbons from reservoirs, fractures will gradually close and their permeabilities will be reduced. Therefore, fracture conductivity will change dynamically during hydrocarbon extract...
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Article
Open AccessTumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
The communication between tumor-derived elements and stroma in the metastatic niche has a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control metastatic niche format...
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Article
Open AccessAdverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) ...
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Article
Open AccessNanowire arrays restore vision in blind mice
The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspi...
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Article
Open AccessEvaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization
In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventr...
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Article
Open AccessIL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using ...
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Article
Open AccessProteomic analysis reveals that auxin homeostasis influences the eighth internode length heterosis in maize (Zea mays)
Ear height is an important maize morphological trait that influences plant lodging resistance in the field, and is based on the number and length of internodes under the ear. To explore the effect of internode...
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Article
Open AccessHuR regulates telomerase activity through TERC methylation
Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein...
