435 Result(s)
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Open AccessAuthor Correction: Cuproptosis-related genes predict prognosis and trastuzumab therapeutic response in HER2-positive breast cancer
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Open AccessCold-induced FOXO1 nuclear transport aids cold survival and tissue storage
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin a...
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Open AccessStructural bases of inhibitory mechanism of CaV1.2 channel inhibitors
The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain an...
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Open AccessBiomimetic nanocluster photoreceptors for adaptative circular polarization vision
Nanoclusters with atomically precise structures and discrete energy levels are considered as nanoscale semiconductors for artificial intelligence. However, nanocluster electronic engineering and optoelectronic...
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Open AccessHigh quality assemblies of four indigenous chicken genomes and related functional data resources
Many lines of evidence indicate that red jungle fowl (RJF) is the primary ancestor of domestic chickens. Although multiple versions of RJF (galgal2-galgal5 and GRCg6a) and commercial chickens (GRCg7b/w and Hux...
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Open AccessN-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution
Planar-chiral cyclophanes have gained considerable concerns for drug discovery due to their unique conformational strain and 3D structure. However, the enantioselective synthesis of planar-chiral cyclophanes i...
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Open AccessInterferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells
The bioactivity of interferon-γ (IFN-γ) in cancer cells in the tumor microenvironment (TME) is not well understood in the current immunotherapy era. We found that IFN-γ has an immunosuppressive effect on color...
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Open AccessNortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway
Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated by numerous studies to have antit...
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Open AccessPMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness
Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces ti...
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Open AccessUltrastrong to nearly deep-strong magnon-magnon coupling with a high degree of freedom in synthetic antiferromagnets
Ultrastrong and deep-strong coupling are two coupling regimes rich in intriguing physical phenomena. Recently, hybrid magnonic systems have emerged as promising candidates for exploring these regimes, owing to...
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Open AccessALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
Cardiac macrophage contributes to the development of cardiac fibrosis, but factors that regulate cardiac macrophages transition and activation during this process remains elusive. Here we show, by single-cell ...
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Open AccesscircRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway
Macrophages act as the first immune defense line of the host against Mycobacterium tuberculosis (Mtb). A previous study showed that circRNA_SLC8A1 was significantly upregulated in Mtb-infected macrophages, but...
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Deep whole-genome analysis of 494 hepatocellular carcinomas
Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1–3. However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4–8, with current a...
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Open AccessEvolution and expression patterns of the neo-sex chromosomes of the crested ibis
Bird sex chromosomes play a unique role in sex-determination, and affect the sexual morphology and behavior of bird species. Core waterbirds, a major clade of birds, share the common characteristics of being s...
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Open AccessMachine learning-based disulfidptosis-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity in hepatocellular carcinoma
Disulfidptosis a new cell death mode, which can cause the death of Hepatocellular Carcinoma (HCC) cells. However, the significance of disulfidptosis-related Long non-coding RNAs (DRLs) in the prognosis and imm...
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Open AccessA landscape of gene expression regulation for synovium in arthritis
The synovium is an important component of any synovial joint and is the major target tissue of inflammatory arthritis. However, the multi-omics landscape of synovium required for functional inference is absent...
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Open AccessResearch on time series prediction of multi-process based on deep learning
Aiming at the problem of data fluctuation in multi-process production, a Soft Update Dueling Double Deep Q-learning (SU-D3QN) network combined with soft update strategy is proposed. Based on this, a time serie...
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Open AccessMolecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors
SAP05, a secreted effector by the obligate parasitic bacteria phytoplasma, bridges host SPL and GATA transcription factors (TFs) to the 26 S proteasome subunit RPN10 for ubiquitination-independent degradation....
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Open AccessSteep-slope vertical-transport transistors built from sub-5 nm Thin van der Waals heterostructures
Two-dimensional (2D) semiconductor-based vertical-transport field-effect transistors (VTFETs) – in which the current flows perpendicularly to the substrate surface direction – are in the drive to surmount the ...
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Open AccessCuproptosis-related genes predict prognosis and trastuzumab therapeutic response in HER2-positive breast cancer
Breast cancer is the most common diagnosed cancer, the HER2-positive subtype account for 15% of all breast cancer. HER2-targeted therapy is the mainstay treatment for HER2-positive breast cancer. Cuproptosis i...
