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Article
Open AccessTissue-resident B cells orchestrate macrophage polarisation and function
B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-ly...
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Article
Open AccessIdentification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous ...
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Article
Open AccessPreclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL...
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Article
An invariant Trypanosoma vivax vaccine antigen induces protective immunity
Trypanosomes are protozoan parasites that cause infectious diseases, including African trypanosomiasis (slee** sickness) in humans and nagana in economically important livestock1,2. An effective vaccine against...
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Article
Open AccessAuthor Correction: Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Gut-educated IgA plasma cells defend the meningeal venous sinuses
The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges—the membranes that surround the brain and spinal cord—contain a diverse popula...
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Article
Open AccessGenomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae
In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease ove...
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Article
Open AccessLentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder characterised by recurrent and often life-threatening infections and hyperinflammation. It is caused by defects of the phag...
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Article
Open AccessEstablishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
Visceral leishmaniasis is an infectious parasitic disease caused by the protozoan parasites Leishmania donovani and Leishmania infantum. The drugs currently used to treat visceral leishmaniasis suffer from toxici...
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Article
High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation
By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...
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Article
Open AccessAn African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the anti...
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Article
Adaptation of host transmission cycle during Clostridium difficile speciation
Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic and phenotypic properties. However, the selective forces that affect genetic adaptations and how they relate to t...
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Chapter
Right Asepsis with ANTT® for Infection Prevention
Aseptic technique, which involves infection prevention actions designed to protect patients from infection when undergoing invasive clinical procedures, is universally prescribed by guideline makers as a criti...
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Article
Open AccessAlpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlap** regions of chromosome 3 have been assoc...
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Article
Open AccessPreclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease
TNFα is an important cytokine in inflammatory bowel disease. V565 is a novel anti-TNFα domain antibody developed for oral administration in IBD patients, derived from a llama domain antibody and engineered to ...
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Article
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization
Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.
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Article
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway
Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs c...
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Article
C13orf31 (FAMIN) is a central regulator of immunometabolic function
Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation a...
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Article
T cell fate and clonality inference from single-cell transcriptomes
The TraCeR tool extracts full-length, paired T cell receptor sequences from single-cell RNA-sequencing data from T lymphocytes, enabling a combination of clonotype and functional analysis.
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Article
Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host
Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host specie...
