48 Result(s)
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Article
Application of endoscopic Ho:YAG laser incision technique treating urethral strictures and urethral atresias in pediatric patients
Endoscopic holmium:yttrium–aluminum–garnet (Ho:YAG) laser incision is a new method applied in pediatric urology recent years. To evaluate its therapeutic efficacy on treating the pediatric patients with urethr...
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Results of RS-99 protocol for childhood solid tumors
Little was known about the therapeutic result of rhabdomyosarcomas (RMSs) and other malignant tumors until the end of the last century in China. Very few prospective clinical research results have been reporte...
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Article
Human coronavirus NL63 in hospitalized children with respiratory infection: A 2-year study from Chongqing, China
Human coronavirus (HCoV) NL63, a newly discovered coronavirus, has been associated with acute lower respiratory tract infections (ALRTI). We detected HCoV-NL63 via reverse transcriptional PCR (RT-PCR) in eight...
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Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups
We showed that intrauterine growth restriction (IUGR) increases distal airspace wall thickness at birth (postnatal age 0; P0) in rat pups (saccular stage of lung development). However, that report did not asse...
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Dyssynchronous ventricular contraction in Wolff–Parkinson–White syndrome: a risk factor for the development of dilated cardiomyopathy
Emerging evidence suggests that significant left ventricular dysfunction may arise in right-sided septal or paraseptal accessory pathways (APs) with Wolff–Parkinson–White syndrome, even in the absence of recur...
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Article
Surfactant reduced the mortality of neonates with birth weight ⩾1500 g and hypoxemic respiratory failure: a survey from an emerging NICU network
We evaluated the efficacy of surfactant therapy and assisted ventilation on morbidity and mortality of neonates with birth weight (BW) ⩾1500 g and hypoxemic respiratory failure (HRF).
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Intrauterine growth retardation-associated syncytin b hypermethylation in maternal rat blood revealed by DNA methylation array analysis
Emerging evidence suggests that DNA methylation in maternal blood is a promising target for intrauterine growth retardation (IUGR) screening, a common developmental toxicity. Here, we aimed to screen out IUGR-...
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Article
Histone deacetylase-2 expression and activity in children with nephrotic syndrome with different glucocorticoid response
Glucocorticosteroid (GC) is one of the most effective drugs available for the treatment of primary nephrotic syndrome (PNS) in children. However, some patients show little or no response to GC. The purpose of ...
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Article
Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children
Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) is a common complication especially in pediatric population. Plasma gelsolin (pGSN) is an anti-inflammatory factor through binding with actin and pr...
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Antibiotic usage in Chinese children: a point prevalence survey
Children as a population have high antimicrobial prescribing rates which may lead to high resistance of bacteria according to data from some single-center surveys of antibiotic prescribing rates in China. The ...
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Article
Chinese clinical practice guidelines for acute infectious diarrhea in children
The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population.
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Article
A negative regulator of synaptic development: MDGA and its links to neurodevelopmental disorders
Formation of protein complexes across synapses is a critical process in neurodevelopment, having direct implications on brain function and animal behavior. Here, we present the understanding, importance, and p...
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Open AccessEstablishment of an efficient reverse genetic system of Mumps virus S79 from cloned DNA
Mumps is a common type of respiratory infectious disease caused by mumps virus (MuV), and can be effectively prevented by vaccination. In this study, a reverse genetic system of MuV that can facilitate the rat...
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Attenuated MuV-S79 as vector stably expressing foreign gene
To describe mumps virus (MuV) used as a vector to express enhanced green fluorescent protein (EGFP) or red fluorescent protein (RFP) genes.
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Open AccessSevere clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) deficiency is an autosomal recessive inborn error of metabolism, which will give rise to failure of ketogenesis in liver during illness or fasting. I...
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Open AccessShort-term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008–2017
An increasing number of extremely preterm (EP) infants have survived worldwide. However, few data have been reported from China. This study was designed to investigate the short-term outcomes of EP infants at ...
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Article
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition)
In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagno...
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Best practice for infection prevention in pediatric respiratory clinics during the COVID-19 epidemic
During the COVID-19 epidemic, it is important for ensuring infection prevention and control in the pediatric respiratory clinics. Herein, we introduced the practice of infection prevention and control in pedia...
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Open AccessClinical and imaging features of pediatric COVID-19
Pediatric COVID-19 is relatively mild and may vary from that in adults. This study was to investigate the epidemic, clinical, and imaging features of pediatric COVID-19 pneumonia for early diagnosis and treatm...
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Article
Surrogate markers and predictors of endogenous insulin secretion in children and adolescents with type 1 diabetes
No studies have examined endogenous insulin secretion in pediatric patients with type 1 diabetes in China using the gold-standard mixed-meal tolerance test. Because the latter is labor-intensive, we examined s...
