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Sol–gel-assisted synthesis of PVPO-TiO2 nanocomposites extended to bifunctionality as efficient electrode for enzymeless D-( +)-glucose sensing and antimicrobial potential

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Abstract

A novel polyvinylpyrrolidone oxime and titanium dioxide nanocomposite (PVPO-TiO2 NC)-based enzymeless glucose sensing electrode was fabricated and characterized to evaluate its performance. A facile sol–gel approach was adopted to fabricate the NCs as a novel product. PVPO-TiO2 NCs were coated onto the surface of a graphite sheet electrode using a drop-casting method. The NCs and modified electrode were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), ultraviolet–visible (UV–Vis) spectroscopy, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), tunneling electron microscopy (TEM), and zeta potential measurements for their structural, morphological, and spectral analysis. The electrochemical behavior of the modified PVPO-TiO2/G electrode was studied by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry (CA). The modified electrode demonstrated high sensitivity of 62.79 µA/mMcm2, a low detection limit of 445.3 µM, and a linear range of 0–16 mM with a regression coefficient R2 = 0.982. Also, this composite electrode delivered good stability, anti-interference ability with species including fructose, ascorbic acid (AA), and uric acid (UA), and effective detection in common beverage samples. In addition, PVPO-TiO2 NCs effectively inhibited harmful pathogenic bacteria including Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Shigella flexneri in antimicrobial analysis. Subsequently, PVPO-TiO2 NCs, due to their dual functionality, proved to be an efficient glucose sensor as well as a good inhibitor against these problematic microbes. In this way, the novel composite obtained through this approach may be recommended to provide better performance, with bifunctional behavior toward both glucose sensing and inhibition of harmful microbes.

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Acknowledgements

The authors are grateful to CSIR, Delhi, India, for providing a fellowship to Meena (award letter no. 16/06/2019(i) EU-V) and Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Sonepat, Haryana, for providing necessary facilities.

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  1. Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal-131039, Sonipat, Haryana, India

    Meena Yadav & Suman Lata

  2. Department of Biomedical Engineering, Deenbandhu Chhotu Ram University of Science and Technology, Murthal-131039, Sonipat, Haryana, India

    Geeta Singh

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Yadav, M., Singh, G. & Lata, S. Sol–gel-assisted synthesis of PVPO-TiO2 nanocomposites extended to bifunctionality as efficient electrode for enzymeless D-( +)-glucose sensing and antimicrobial potential. J Solid State Electrochem 26, 2153–2170 (2022). https://doi.org/10.1007/s10008-022-05216-9

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