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Voltammetric nonenzymatic sensing of glucose by using a porous nanohybrid composed of CuS@SiO2 spheres and polypyrrole

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Abstract

Porous spheres of CuS@SiO2 were obtained by deposition of CuS on silica spheres through a one-step chemical method. Subsequently, polypyrrole (PPy) was deposited on the CuS@SiO2 spheres. The formation of the porous spheres was elucidated by control experiments and physical characterizations. The nanohybrid was placed on a glassy carbon electrode (GCE) surface where it displays good electrocatalytic activity in terms of glucose electrooxidation with an optimum at a working potential of 0.55 V (vs. Ag/AgCl) in 0.1 M NaOH solution. The PPy-CuS@SiO2 achieves an extremely high sensitivity (505.3 μA mM−1 cm−2), wide linear range (10 μM–4.2 mM), low detection limit (1.0 μM), short response time (˂ 0.5 s), high selectivity, long-term durability, and reproducibility. The fabricated electrode based on PPy-CuS@SiO2 was further used for the determination of glucose in blood sample with good recoveries.

Schematic representation of the method for fabrication of polypyrrole-coated porous CuS@SiO2 sphere.

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Funding

Dr. S. Radhakrishnan received the DST-Inspire Faculty Award (DST/INSPIRE/04/2015/002259) from the DST, New Delhi, India. This work was supported by the National Research Foundation of Korea (NRF-2019R1F1A1059831).

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Authors and Affiliations

  1. Electronics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute, Karaikudi, Tamilnadu, 630 003, India

    Sivaprakasam Radhakrishnan

  2. Department of Chemistry, Kongju National University, 56 Gongjudaehak-ro, Gongju-si, Chungnam-do, 32588, Republic of Korea

    Vinoth Ganesan & **kwon Kim

Authors
  1. Sivaprakasam Radhakrishnan
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  2. Vinoth Ganesan
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  3. **kwon Kim
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Correspondence to Sivaprakasam Radhakrishnan or **kwon Kim.

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Radhakrishnan, S., Ganesan, V. & Kim, J. Voltammetric nonenzymatic sensing of glucose by using a porous nanohybrid composed of CuS@SiO2 spheres and polypyrrole. Microchim Acta 187, 260 (2020). https://doi.org/10.1007/s00604-020-04227-5

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