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Angiogenesis in hepatocellular carcinoma

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Abstract

The published data concerning angiogenesis processes in hepatocellular carcinoma are systematized in the present review. The basic morphogenetic steps of neovascularization, namely, sinusoidal capillarization, tissue arterialization, and vascular mimicry and cooperation, are considered. A detailed analysis of activators and inhibitors of angiogenesis in tumors in general, and hepatocellular carcinoma in particular, is presented. The key parameters of angiogenesis and growth factors associated with clinical characteristics and prognosis of the disease are enumerated. The progressive increase in blood supply through the hepatic artery and consequent reduction of blood flow through the portal vein system concomitantly to the increase of the degree of malignancy of hepatocellular carcinoma are emphasized. Special attention is paid to the development of approaches for the detection of markers for specific stages of angiogenesis and antiangiogenic therapies for malignant tumors.

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Authors and Affiliations

  1. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, ul. Akademika Oparina 4, Moscow, 117997, Russia

    U. N. Tumanova & A. I. Shchegolev

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  1. U. N. Tumanova
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  2. A. I. Shchegolev
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Correspondence to U. N. Tumanova.

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Original Russian Text © U.N. Tumanova, A.I. Shchegolev, 2015, published in Uspekhi Sovremennoi Biologii, 2015, Vol. 135, No. 2, pp. 164–176.

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Tumanova, U.N., Shchegolev, A.I. Angiogenesis in hepatocellular carcinoma. Biol Bull Rev 5, 568–578 (2015). https://doi.org/10.1134/S2079086415060080

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