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Antidiabetic potential and multi-biological activities of Trachystemon orientalis extracts

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Abstract

Due to the increase in exposure to chemical substances, the investigation of natural compounds with protective effects has become popular. So in this study the antimicrobial, antioxidant, antimutagenic activities and enzyme inhibitory effects of Trachystemon orientalis leaf and stem extracts were investigated. Antimicrobial effect was determined by disc diffusion method and the antimutagenic effect was investigated by Ames/Salmonella/microsomal test. Antioxidant properties of T. orientalis extracts were determined by investigating the phytochemical contents and 2,2-diphenyl-1-picrylhydrazyl (DPPH) removal activity. The antidiabetic activity of the extracts was investigated by α-amylase and α-glucosidase enzyme inhibition. It has been determined that all extracts exhibit antimicrobial activity at different ratios and the highest antimicrobial activity was obtained with a 21 ± 0.4 mm inhibition zone against Escherichia coli. The highest DPPH removal activity of leaf and stem extracts was determined to be 65.1 ± 2.4% and 59.4 ± 2.7%, respectively. In enzyme inhibitory analysis, it was determined that the α-glucosidase inhibitory effect of extracts was higher than the α-amylase inhibition effect. In antimutagenity test, the highest antimutagenic effects of leaf and stem extract were determined as 78.2 ± 1.1% and 67.2 ± 1.5%, respectively. As a result, T. orientalis leaf and stem extracts were determined as a potential natural antimicrobial, antimutagenic and antioxidant source with a moderately high antidiabetic activity.

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Abbreviations

ACE:

Acarbose equivalent

BHA:

Butylated hydroxytoluene

BHT:

Butylated hydroxyanisole

DPPH:

2,2-diphenyl-1-picrylhydrazyl

GAE:

Gallic acide equivalent

QAE:

Quillaja equivalent

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Authors and Affiliations

  1. Department of Biology, Faculty of Science and Art, University of Giresun, Giresun, Turkey

    Burhanettin Sertaç Ayhan, Emine Yalçın & Kültiğin Çavuşoğlu

  2. Department of Medical Services and Techniques, Vocational School of Health Services, University of Giresun, Giresun, Turkey

    Ali Acar

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  1. Burhanettin Sertaç Ayhan
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  2. Emine Yalçın
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  3. Kültiğin Çavuşoğlu
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Correspondence to Emine Yalçın.

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Ayhan, B., Yalçın, E., Çavuşoğlu, K. et al. Antidiabetic potential and multi-biological activities of Trachystemon orientalis extracts. Food Measure 13, 2887–2893 (2019). https://doi.org/10.1007/s11694-019-00209-1

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