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Non-neoplastic salivary gland diseases in children: a 10-year review at a tertiary center

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Abstract

Objectives

Non-neoplastic salivary gland diseases are rare in children. This paper aims to present the spectrum of encountered non-neoplastic salivary gland diseases at a tertiary center by describing the demographics, clinical characteristics, and outcomes in this patient population.

Methods

A review of electronic medical records was performed from 2010 until 2020. Relevant data were retrieved and charted according to the type of salivary gland disease. A comparison between diseases was made for demographics, presenting symptoms, treatment, and outcomes.

Results

Fifty patients with 11 different non-neoplastic salivary gland diseases were identified. Sialolithiasis was the most prevalent condition (12/50), with 83% localized in the submandibular gland. In contrast to gender, age, and symptoms, the location of pathology was significantly associated with the diagnosis (p < 0.001). In patients with sialolithiasis, a hybrid procedure (combined endoscopy and lithotomy) resulted in 100% resolution of symptoms. For (plunging) ranula, marsupialisation had a relative risk of recurrence of 9.6 compared to (partial) extirpation of the sublingual gland.

Conclusions

Children with salivary gland diseases present with overlap** symptoms, making clinical diagnosis challenging. The present study may aid physicians and specialists in diagnosing the most prevalent conditions in children. Although no gold standards exist for their treatment, hybrid procedures (sialolithiasis) and subglingual gland extirpation (ranula) showed superior results over alternatives.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Kapucijnenvoer 33, 3000, Leuven, Belgium

    Jonas Ver Berne, Katrien Brijs, Ruxandra Coropciuc & Constantinus Politis

  2. Department of Imaging & Pathology, Group Biomedical Sciences, OMFS-IMPATH, Catholic University of Leuven, Kapucijnenvoer 33, 3000, Leuven, Belgium

    Jonas Ver Berne, Katrien Brijs, Ruxandra Coropciuc & Constantinus Politis

Authors
  1. Jonas Ver Berne
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  2. Katrien Brijs
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  3. Ruxandra Coropciuc
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  4. Constantinus Politis
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Contributions

JVB contributed to the study conception and design. Material preparation, data collection, and analysis were performed by JVB and KB. The first draft of the manuscript was written by JVB and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Katrien Brijs.

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The authors declare no competing interests.

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Ethical approval was obtained from the Ethics Committee for Research from the University Hospitals (reference number S66048).

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The authors declare no competing interests.

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Ver Berne, J., Brijs, K., Coropciuc, R. et al. Non-neoplastic salivary gland diseases in children: a 10-year review at a tertiary center. Oral Maxillofac Surg 27, 693–697 (2023). https://doi.org/10.1007/s10006-022-01103-9

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  • DOI: https://doi.org/10.1007/s10006-022-01103-9

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