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Rapid automated iterative small-molecule synthesis
Automated iterative small-molecule synthesis has the potential to advance and democratize the discovery of new medicines, materials and many other...
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Screening of small molecule compounds targeting hnRNPA2 protein
Heterogeneous nuclear ribonucleoprotein A2, as an RNA binding protein, participates in the processing and metabolism of RNA molecules. HnRNPA2 is...
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Enhanced map** of small-molecule binding sites in cells
Photoaffinity probes are routinely utilized to identify proteins that interact with small molecules. However, despite this common usage, resolving...
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Efficient all-small-molecule organic solar cells processed with non-halogen solvent
All-small-molecule organic solar cells with good batch-to-batch reproducibility combined with non-halogen solvent processing show great potential for...
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Small-molecule discovery through DNA-encoded libraries
The development of bioactive small molecules as probes or drug candidates requires discovery platforms that enable access to chemical diversity and...
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SARS-CoV-2 Resistance to Small Molecule Inhibitors
Purpose of the ReviewSARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern...
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Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease
Post-infectious conditions present major health burdens but remain poorly understood. In Chagas disease (CD), caused by Trypanosoma cruzi parasites,...
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Targeting the human gut microbiome with small-molecule inhibitors
The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However, the detailed molecular...
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Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries
The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and...
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Advancements in Small Molecule Fluorescent Probes for Superoxide Anion Detection: A Review
Superoxide anion (O 2 •− ), a significant reactive oxygen species (ROS) within biological systems, plays a widespread role in cellular function...
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A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ
Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased...
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Challenges and opportunities of develo** small-molecule therapies for age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in senior adults. The disease can be categorized into two types: wet AMD...
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Biophysical Analysis of Small Molecule Binding to Viral RNA Structures
RNA molecules are essential for carrying genetic information and regulating gene expression in most organisms including human pathogenic RNA and...
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Efficacy and safety study of targeted small-molecule drugs in the treatment of systemic lupus erythematosus
BackgroundTargeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention from clinical...
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Small molecule autoencoders: architecture engineering to optimize latent space utility and sustainability
Autoencoders are frequently used to embed molecules for training of downstream deep learning models. However, evaluation of the chemical information...
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Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics
Long-wavelength, near-infrared small-molecule dyes are attractive in biophotonics. Conventionally, they rely on expanded aromatic structures for...
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CineMol: a programmatically accessible direct-to-SVG 3D small molecule drawer
Effective visualization of small molecules is paramount in conveying concepts and results in cheminformatics. Scalable vector graphics (SVG) are...
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Small-molecule organic electrode materials for rechargeable batteries
Small-molecule organic electrode materials (SMOEMs) have shown tremendous potential as cathodes or anodes for various rechargeable batteries...
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Small molecule metabolites: discovery of biomarkers and therapeutic targets
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of...
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Enabling programmable dynamic DNA chemistry using small-molecule DNA binders
The binding of small molecules to the double helical structure of DNA, through either intercalation or minor groove binding, may significantly alter...
