Search
Search Results
-
Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate
PurposeThis study aimed to investigate clinical pharmacokinetics (PKs) of choline after oral administration of choline alfoscerate capsule and newly...
-
Liquid-filled hard capsule formulation of choline alfoscerate: preparation and in vitro/in vivo evaluation
PurposeThe objective of this study was to develop a liquid-filled hard capsule (LFHC) formulation of choline alfoscerate (CA) by screening with empty...
-
Selection of Neuroprotective Therapy in Patients with Chronic Cerebral Ischemia Taking Account of the Synergism of Drug Interactions
Objective. To optimize selection of neuroprotective treatment protocols in patients with chronic cerebral ischemia taking account of synergism in...
-
Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review
In mild cognitive impairment (MCI) due to Alzheimer disease (AD), also known as prodromal AD, there is evidence for a pathologic shortage of uridine,...
-
Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus
Paroxysmal positional nystagmus frequently occurs in lesions involving the cerebellum, and has been ascribed to disinhibition and enhanced canal...
-
Stress, Asthenia, and Cognitive Disorders
Asthenia is a clinical syndrome that can be manifest in almost all somatic, infectious, and neurological diseases. Initially a protective mechanism...
-
Strategies for develo** Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models
BackgroundAs the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts...
-
Features of Planning and Conducting Bioequivalence Studies with an Adaptive Design for Drug Analogs of Endogenous Compounds
There is a constant interest in the study of drugs that are analogs of endogenous compounds. Guidelines for conducting bioequivalence studies are...
-
Lipids in Pollen
Lipids are one of the three main components of pollen grains. A wide spectrum of these compounds is located in both the outer zones (pollenkitt,...
-
Selection of Adaptive Designs in Studies of Bioequivalence. Decision Criteria
Adaptive designs can be selected for bioequivalence studies of drugs for which there are no data on the variability of pharmacokinetic parameters...
-
Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study
BackgroundFocused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of...
-
Analysis of medical services provided to patients with peripheral facial palsy in Korea: a descriptive, cross-sectional study of the health insurance review and assessment service national patient sample database
BackgroundThis cross-sectional, retrospective, observational study analyzed the demographics of patients with peripheral facial palsy in South Korea...
-
Post-Covid Asthenia Syndrome
Objectives. To evaluate the efficacy and safety of combination therapy for patients with post-COVID asthenia syndrome (AS) using the multicomponent...
-
Association between the presence of delirium during intensive care unit admission and cognitive impairment or psychiatric problems: the Korean ICU National Data Study
ObjectiveDelirium in the intensive care unit (ICU) may be a preventable risk factor for cognitive impairment or psychiatric problems. We aimed to...
-
Prospects for the Use of Intranasally Administered Insulin and Insulin-Like Growth Factor-1 in Cerebral Ischemia
AbstractCurrent approaches to the treatment of stroke have significant limitations, and neuroprotective therapy is ineffective. In view of this,...
-
Studies of the Efficacy of Cereton in Mild Cognitive Impairment of the Amnestic Type Based on Testing Lipid Markers
Objectives. To determine the efficacy and safety of treatment with Cereton (alfoscerate) in patients with mild cognitive impairment syndrome (MCI)...