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Scaffolds of Purine Privilege for Biological Cytotoxic Targets: A Review
The primary aim of this review is to emphasize and guide the biological cytotoxic activities of purine scaffold, also with a focus on emerging purine...
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Current Advancements for New Drug Discovery Against Dengue Virus: A Review (2015 – 2020)
Dengue fever is a viral ailment mostly found in tropical and sub-tropical communities. Dengue fever is spread by the mosquito Aedes aegypti....
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Spectrophotometric Determination of Flurbiprofen in Application to Pharmaceutical Analysis
A new simple, rapid, and sensitive spectrophotometric method for the determination of flurbiprofen in pharmaceutical preparations was developed and...
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Development and Validation of a Stability-Indicating HPLC-DAD Method for the Determination of Canagliflozin and Metformin Simultaneously in Combination Dosage Form
The purpose of this study was to develop and validate a rapid, simple, easy, and precise high-performance liquid chromatography (HPLC) method with...
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Synthesis and anticancer activity of 4-aza-daurinol derivatives
Daurinol, a natural aryl naphthalene lactone, has been reported to have antiproliferative activity against various cell lines, and has also been...
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Newest Results on the Chemistry and Pharmacology of TCM Drugs Containing Triterpene and Steroid Saponins
The aim of this review is to provide newest results in the chemistry, pharmacology, and clinical studies of saponins-containing TCM drugs, some of...
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Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the...
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Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats
Chlorogenic acid (5-O-caffeoylquinic acid, CA), a phenolic compound found ubiquitously in plants, has antidiabetic effect in diabetic animal models....
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Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives
New substituted aroylhydrazones ( 4a-f ) were synthesized from the acid hydrazide ( 3 ) and the corresponding aldehyde or aldose. 5-Amino-4-cyano- 1H -pyraz...
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Antimicrobial activity of a new series of benzimidazole derivatives
Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazolehydrazone compounds were synthesized to screen their...
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Design and synthesis of 3′-fluoropenciclovir analogues as antiviral agents
Based on fluorine switch approach, a series of 3′-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and...
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Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides
A number of N - and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with...
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Recent advances in transdermal drug delivery
Transdermal delivery of pharmacologically active agents has been extensively studied for the past 40 years. Despite the strong efforts, currently,...
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Novel approaches on prodrug based drug design
Prodrug design is really not different from the general drug discovery process, in which a unique substance is observed to have desirable...
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Synthesis of novel 2’-methyl carbovir analogues as potent antiviral agents
In this study, the synthesis procedures of 2’-branched carbovir analogues were accomplished. The introduction of a methyl group in the requisite...
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Synthesis of 2′-deoxynucleoside analogs from thioglycosides
The synthesis of pharmacologically active 2′-deoxynucleoside analogs, namely 2′,3′-dideoxythymidine (I) and 2′,3′-dideoxy-3′-fluorothymidine (II), is...
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Pharmacokinetics and bioequivalence evaluation of risperidone in healthy male subjects with different CYP2D6 genotypes
The aim of this study was to evaluate the bioequivalence of risperidone in healthy male subjects representing different CYP2D6 , genotypes with respect...
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Oryza sativa
Oryza sativa is a perennial, cultivated as an annual of the POACEAE (GRAMINEAE) family. The root system of the plant is fibrous, with...
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Substrate Oxidation by Cytochrome P450 Enzymes
Cytochrome P450 mechanisms continue to surprise and delight, although the field is growing to maturity and the completely unexpected is less...
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Progress in Antisense Technology
With the recent FDA approval of Vitravene™, the first drug based on antisense technology to be commercialized, the new technology has achieved an...