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Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides

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Abstract

A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.

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  1. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

    Mohammed T. Abdel-Aal

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Abdel-Aal, M.T. Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides. Arch. Pharm. Res. 33, 797–805 (2010). https://doi.org/10.1007/s12272-010-0601-y

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