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Cajanus cajan induces mitochondrial-mediated apoptosis via caspase activation and cytochrome c release
BackgroundAttention has recently focused on mitochondrial-mediated apoptosis as a signaling pathway that is disrupted in many diseases involving...
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Impact of Viloxazine Extended-Release Capsules (Qelbree®) on Select Cytochrome P450 Enzyme Activity and Evaluation of CYP2D6 Genetic Polymorphisms on Viloxazine Pharmacokinetics
Background and ObjectiveViloxazine extended-release (ER) [Qelbree ® ] is a nonstimulant attention-deficit/hyperactivity disorder (ADHD) treatment. In...
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Dexmedetomidine attenuates postoperative spatial memory impairment after surgery by reducing cytochrome C
BackgroundAnesthesia and surgery can induce perioperative neurocognitive disorders (PND). Mitochondrial dysfunction has been proposed to be one of...
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Can urinary caspase-3 and cytochrome c levels be used as predictive biomarkers in the management of unilateral antenatal hydronephrosis?
PurposeWe aimed to investigate the urinary caspase-3 and cytochrome c levels in patients with unilateral antenatal hydronephrosis and to determine...
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Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis
PurposeArylamine N -acetyltransferase 1 (NAT1) deficiency has been associated with drug resistance and poor outcomes in breast cancer patients. The...
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Whole blood hydroxychloroquine: Does genetic polymorphism of cytochrome P450 enzymes have a role?
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations and multifactorial etiologies ranging...
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Importance of cytochrome 3A4 and 2D6-mediated drug–drug interactions in oxycodone consumption among older adults hospitalized for hip fracture: a cross-sectional study
Hip fracture is a common injury and represents a major health problem with an increasing incidence. In older adults, opioids such as oxycodone are...
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Extended-Release Viloxazine Compared with Atomoxetine for Attention Deficit Hyperactivity Disorder
Background and ObjectiveIn our outpatient pediatric and adult psychiatry centers, we reserve psychostimulants for predominantly inattentive attention...
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USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly incurable and has been recognized as the third leading cause...
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Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release
PurposeSome evidence that non-steroidal anti-inflammatory drugs have neuroprotective effects indicates their potential for use in a new field....
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Treatment of platelet concentrates with the L-carnitine modulates platelets oxidative stress and platelet apoptosis due to mitochondrial reactive oxygen species reduction and reducing cytochrome C release during storage
Platelet concentrate (PC) transfusion is administrated to reduce the hemostatic complications in patients with thrombocytopenia. Strength platelet...
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Involvement of cytochrome P450 enzymes in inflammation and cancer: a review
Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs, xenobiotics, and endogenous substances. This enzymatic activity can...
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The Cytokine Release Syndrome and/or the Proinflammatory Cytokines as Underlying Mechanisms of Downregulation of Drug Metabolism and Drug Transport: A Systematic Review of the Clinical Pharmacokinetics of Victim Drugs of this Drug–Disease Interaction Under Different Clinical Conditions
Background and ObjectiveAn ever-growing body of evidence supports the impact of cytokine modulation on the patient’s phenotypic drug response. The...
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Photobiomodulation induces microvesicle release in human keratinocytes: PI3 kinase-dependent pathway role
Microvesicles (MVs, 100–1000 nm diameter) are released into the extracellular environment by mammalian cells. MVs interact with near or remote cells...
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Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases
BackgroundThere is increasing evidence for the role of inflammation in the pathogenesis of mitochondrial diseases (MDs). However, the mechanisms...
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Comparison of Pharmacokinetic Profiles of Beraprost Sustained Release in Japanese, Chinese, and Korean Healthy Adult Males
Background and ObjectivesBeraprost sodium (BPS), an orally administrable prostaglandin I 2 derivative, is used for the treatment of chronic arterial...
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Experimental and molecular docking studies of quercetin and vitamin E with diabetes-associated mitochondrial-ATPase as anti-apoptotic therapeutic strategies
PurposeResearches have shown the relevance of antioxidants in the management of several diseases. In the present study, the effects of quercetin and...
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A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Efficacy and Safety of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
Background and objectiveAttention-deficit/hyperactivity disorder is a neurodevelopmental disorder that typically begins in childhood and often...
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Oleic acid induces mitochondrial-mediated cell death via mPT pore and protects against estradiol benzoate-induced endometrial hyperplasia in female Wistar rats
Endometrial hyperplasia (EH) is a female gynecological disorder which occurs in women of reproductive age. It has been attributed to excessive...
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Extra-adrenal aldosterone: a mini review focusing on the physiology and pathophysiology of intrarenal aldosterone
PurposeAccumulating evidence has demonstrated the existence of extra-adrenal aldosterone in various tissues, including the brain, heart, vascular,...
