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Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis
Homeodomain transcription factor A9 (HOXA9) is a member of the HOX cluster family of transcription factors that are crucially involved in embryo...
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Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer
PurposeThis study aims to investigate the expression patterns and clinical significance of miR-140-3p and homeobox A9 (HOXA9) in colorectal cancer...
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Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a heterogeneous disorder encompassing a set of hematopoietic tumors that develop when the myeloid precursor...
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A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML
Relapse is a major challenge to therapeutic success in acute myeloid leukemia (AML) and can be partly associated with heterogeneous leukemic stem...
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MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway
BackgroundPrevious studies had shown that microRNA-638 (miR-638) exhibited different effects in malignant tumors. Moreover, the function of miR-638...
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Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia
Chromosome translocations involving the MLL gene are common rearrangements in leukemia. Such translocations fuse the MLL 5’-region to partner genes...
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PHF6 suppresses self-renewal of leukemic stem cells in AML
Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing myeloid progenitors accompanied by a differentiation arrest....
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Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia
In KMT2A -rearranged acute lymphoblastic leukemia (ALL), an aggressive malignancy, oncogenic KMT2A-fusion proteins inappropriately recruit DOT1L to...
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MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also...
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Development and validation of a predictive model in diagnosis and prognosis of primary glioblastoma patients based on Homeobox A family
BackgroundHomeobox A (HOXA) family is involved in the development of malignancies as either tumor suppressors or oncogenes. However, their roles in...
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In silico analysis of differentially expressed-aberrantly methylated genes in breast cancer for prognostic and therapeutic targets
Breast cancer (BC) is the leading cause of death among women across the globe. Abnormal gene expression plays a crucial role in tumour progression,...
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Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia
Scribble complex proteins can influence cell fate decisions and self-renewal capacity of hematopoietic cells. While specific cellular functions of...
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Detection of the DNA methylation of seven genes contribute to the early diagnosis of lung cancer
BackgroundLow-dose Computed Tomography (CT) is used for the detection of pulmonary nodules, but the ambiguous risk evaluation causes overdiagnosis....
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SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
KMT2A -rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization...
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Identification and analysis of methylation signature genes and association with immune infiltration in pediatric acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a common leukemia with low cure rate and poor prognosis among pediatric patients. The regulation of AML...
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Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP
Patients diagnosed with acute lymphoblastic leukemia (ALL) bearing t(4;11)/MLL-AF4 have aggressive clinical features, poor prognosis and there is an...
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Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis
Insufficiency of polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27, is frequently found in primary myelofibrosis and...
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Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells
Engineered T cells have been shown to be highly effective in cancer immunotherapy, although T cell exhaustion presents a challenge for their...
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HOXA9 is a novel myopia risk gene
PurposeA recent meta-analysis revealed PAX6 as a risk gene for myopia. There is a link between PAX6 and HOXA9 . Furthermore, HOXA9 has been reported...
