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Aggregation of gelsolin wild-type and G167K/R, N184K, and D187N/Y mutant peptides and inhibition
Gelsolin, an actin-binding protein, is localized intra- and extracellularly in the bloodstream and throughout the body. Gelsolin amyloidosis is a...
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CAPG is a novel biomarker for early gastric cancer and is involved in the Wnt/β-catenin signaling pathway
Past studies have shown that the Gelsolin-like actin-cap** protein (CAPG) regulates cell migration and proliferation and is strongly associated...
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Novel inter-domain Ca2+-binding site in the gelsolin superfamily protein fragmin
Gelsolin superfamily proteins, consisting of multiple domains (usually six), sever actin filaments and cap the barbed ends in a Ca 2+ -dependent...
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The Actin Cytoskeleton in Pollen Tubes; Actin and Actin Binding Proteins
Actin cytoskeleton is well known to be a key element for the germination and the elongation of pollen tubes. It has been appreciated that the...
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Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis
Charting the emergence of eukaryotic traits is important for understanding the characteristics of organisms that contributed to eukaryogenesis....
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Sulfated Glucuronorhamnoxylan from Capsosiphon fulvescens Ameliorates Osteoporotic Bone Resorption via Inhibition of Osteoclastic Cell Differentiation and Function In Vitro and In Vivo
Excessive osteoclast differentiation and/or bone resorptive function causes a gradual loss of bone, leading to the pathogenesis of bone diseases such...
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Optogenetic Activation of Intracellular Nanobodies
Intracellular antibody fragments such as nanobodies and scFvs are powerful tools for imaging and for modulating and neutralizing endogenous target...
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The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions
Caspase-2 represents an evolutionary conserved caspase, which plays a role in genotoxic stress-induced apoptosis, ageing-related metabolic changes,...
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Gelsolin of insect vectors negatively regulates actin-based tubule motility of plant reoviruses
Most plant reoviruses encode a type of nonstructural protein that assembles tubular structures to package virions for viral spread in planthopper or...
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The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties
Mutations in the gelsolin protein are responsible for a rare conformational disease known as AGel amyloidosis. Four of these mutations are hosted by...
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Semi-purified Antimicrobial Proteins from Oyster Hemolymph Inhibit Pneumococcal Infection
Pneumococcal infections caused by Streptococcus pneumoniae are a leading cause of morbidity and mortality globally, particularly among children. The...
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Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram
Protein–protein interactions are essential for normal cellular processes and signaling events. Defining these interaction networks is therefore...
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FYB1-targeted modulation of CAPG promotes AML progression
Acute myeloid leukemia (AML) is a rare and heterogeneous disease. Over the past few decades, patient prognosis has improved with continuous...
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The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs
The Z-disk of striated muscle defines the ends of the sarcomere, which repeats many times within the muscle fiber. Here we report application of...
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Deletions in GSN gene associated with growth traits of four Chinese cattle breeds
The aim of this study was to assess the potential of 21 bp mutation in the second intron of the GSN gene as a molecular marker-assisted by exploring...
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Recessive TMOD1 mutation causes childhood cardiomyopathy
Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic...
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Super-enhancer-associated gene CAPG promotes AML progression
Acute myeloid leukemia is the most common acute leukemia in adults, the barrier of refractory and drug resistance has yet to be conquered in the...
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Phagocytosis
One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was the first to observe the uptake of particles by cells and...
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Expression of genes regulating cell division in porcine follicular granulosa cells
BackgroundCell cycle regulation influences the proliferation of granulosa cells and affects many processes related to ovarian folliclular growth and...
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Imaging Cytoskeleton Components by Electron Microscopy
The cytoskeleton is a complex of detergent-insoluble components of the cytoplasm playing critical roles in cell motility, shape generation, and...