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Phagocytosis

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Intracellular Pathogens

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2813))

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Abstract

One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was the first to observe the uptake of particles by cells and realized the importance of this process, named phagocytosis, for the host response to injury and infection. He also was a strong advocate of the role of phagocytosis in cellular immunity, and with this, he gave us the basis for our modern understanding of inflammation and the innate immune response. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation. In this chapter, we present a general view of our current knowledge on phagocytosis performed mainly by professional phagocytes through antibody and complement receptors and discuss aspects that remain incompletely understood.

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Acknowledgments

Research in the authors’ laboratory was supported by grant PAPIIT IN205523 from Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México, Mexico, and grant CF-2023-I-610 from Consejo Nacional de Humanidades, Ciencia y Tecnología (CONAHCyT), Mexico.

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  1. Laboratorio de Biología del Desarrollo, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, Mexico

    Eileen Uribe-Querol

  2. Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico

    Carlos Rosales

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  1. Eileen Uribe-Querol
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  2. Carlos Rosales
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Correspondence to Carlos Rosales .

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  1. Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada

    Aneesh Thakur

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Uribe-Querol, E., Rosales, C. (2024). Phagocytosis. In: Thakur, A. (eds) Intracellular Pathogens. Methods in Molecular Biology, vol 2813. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3890-3_3

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