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Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors
CD22, one of the sialic acid-binding immunoglobulin-like lectins (Siglecs), regulates B lymphocyte signaling via its interaction with glycan ligands...
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High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy
Chimeric antigen receptors (CARs) offer a promising new approach for targeting B cell malignancies through the immune system. Despite the proven...
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Production and characterization of a camelid single domain anti-CD22 antibody conjugated to DM1
Antibody drug conjugates (ADCs) with twelve FDA approved drugs, known as a novel category of anti-neoplastic treatment created to merge the...
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Functional Study of a Camelid Single Domain Anti-CD22 Antibody
Variable antigen-binding domain of camelid single chain antibodies (VHH, Nanobody) and its conjugates are considered among very promising candidates...
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Donor-derived CAR-T therapy improves the survival of relapsed B-ALL after allogeneic transplantation compared with donor lymphocyte infusion
Chimeric antigen receptor (CAR)-T cell therapy revolutionized treatment for various hematologic malignances. However, limited studies were reported...
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Molecular dynamics simulations, docking and MMGBSA studies of newly designed peptide-conjugated glucosyloxy stilbene derivatives with tumor cell receptors
In this work, for the first time, we designed derivatives of beta-D-glucosyloxy-3-hydroxy-trans-stiblene-2-carboxylic acid (GHS), by conjugating GHS...
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Liver Transcriptome Analysis Reveals Energy Regulation and Functional Impairment of Onychostoma sima During Starvation
Releasing juvenile fish into resource-depleted waters is regarded as an effective way to restore fishery resources. However, during this stage,...
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Differential miRNA expression profiles in the bone marrow of Beagle dogs at different stages of Toxocara canis infection
BackgroundToxocara canis is distributed worldwide, posing a serious threat to both human and dog health; however, the pathogenesis of T. canis ...
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Sialic Acid-Binding Ig-Like Lectins (Siglecs)
During the mid-1980s, in vitro rosette formation between macrophages and sheep erythrocytes was reported; however, sialidase treatment on...
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Combinatorial metabolomic and transcriptomic analysis of muscle growth in hybrid striped bass (female white bass Morone chrysops x male striped bass M. saxatilis)
BackgroundUnderstanding growth regulatory pathways is important in aquaculture, fisheries, and vertebrate physiology generally. Machine learning...
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Pharmacokinetic Study of Antibody-Drug Conjugates
The metabolism of antibody-drug conjugates (ADCs) is one of the key factors affecting the therapeutic effect. The pharmacokinetic properties of ADCs...
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The Role of Cancer-Specific Target Antigens in CAR T Cell Therapy in Hematological Malignancies
Purpose of ReviewCAR T cell therapy has revolutionized the cancer therapy. However, for an effective therapy, selecting an ideal target antigen on...
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Monoclonal Antibodies in Oncology: A Decade of Novel Options
Several decades of research and clinical trials have conclusively provided proof of concept on the usefulness of monoclonal antibodies in the...
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Generation of Single-Domain Antibody-Based Recombinant Immunotoxins
The discovery of single-domain antibodies has opened new avenues for drug development. Single-domain antibodies, also known as nanobodies, can access...
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Identification of Genes Related to Resistance to Ichthyophthirius multifiliis Based on Co-expression Network Analysis in Grass Carp
The ciliate protozoan Ichthyophthirius multifiliis is an essential parasite causing white spot disease in grass carp, leading to significant economic...
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Identification of Siglec Cis-Ligands by Proximity Labeling
Siglecs are known to be bound and regulated by membrane molecules that display specific sialic acid-containing ligands and are present on the same...
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Chimeric Antigen Receptor CAR-T Therapy on the Move: Current Applications and Future Possibilities
Purpose of ReviewChimeric antigen receptor CAR-T therapy is a rowing therapeutic approach in hematological malignancies and certain solid tumors....
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Adiponectin and Its Effects on Acute Leukemia Cells: An Experimental and Bioinformatics Approach
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. It is known that deregulation of adipokine pathways is probably...
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Antibody-Drug Conjugates: Basic Concepts and Structures
Antibody-drug conjugates (ADCs) are new modality of anticancer therapeutics. To enhance the translation, three components of an ADC drug—antibody,...