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eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity
The roles of nitric oxide (NO) and endothelial NO synthase (eNOS) in the regulation of angiogenesis are well documented. However, the involvement of...
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The role of oxidative stress in the pathogenesis of ocular diseases: an overview
Dysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological...
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PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies
BackgroundNeovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation,...
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Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease
The blood-retinal barrier (BRB) creates the defined retinal environment necessary for neuronal signaling and vision. The well-developed tight...
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Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts that are longer than 200 nucleotides in length. LncRNAs are implicated in gene...
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Long-lasting impairments in rodent oxygen-induced retinopathy measured by retinal vessel density and visual function
In mild or moderate retinopathy of prematurity (ROP), retinal vessels undergo obliteration, proliferation, and regression. Despite complete...
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Reduction of high glucose-induced oxidative injury in human retinal pigment epithelial cells by sarsasapogenin through inhibition of ROS generation and inactivation of NF-κB/NLRP3 inflammasome pathway
BackgroundHyperglycemia-induced accumulation of reactive oxygen species (ROS) is a major risk factor for diabetic retinopathy (DR). Sarsasapogenin is...
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Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that...
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Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina
BackgroundDiabetic retinopathy, a major complication of diabetes mellitus, is a leading cause of sigh-loss in working age adults. Progressive loss of...
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Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in...
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Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The...
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Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice
Circadian clocks in the mammalian retina regulate a diverse range of retinal functions that allow the retina to adapt to the light-dark cycle....
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Gut microbiota in relationship to diabetes mellitus and its late complications with a focus on diabetic foot syndrome: A review
Diabetes mellitus is a chronic disease affecting glucose metabolism. The pathophysiological reactions underpinning the disease can lead to the...
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Genome-wide association identifies novel ROP risk loci in a multiethnic cohort
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major...
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Glial cell alterations in diabetes-induced neurodegeneration
Type 2 diabetes mellitus is a global epidemic that due to its increasing prevalence worldwide will likely become the most common debilitating health...
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Potential Antioxidant Enzymes from Fungi and Their Clinical Significance
Fungi are a group of heterotrophic eukaryotes capable of producing an array of enzymes. Most of the fungal enzymes are being used successfully in...
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Circular RNA RSU1 promotes retinal vascular dysfunction by regulating miR-345-3p/TAZ
Diabetic mellitus-induced diabetic retinopathy is a significant cause of visual impairment and blindness in adults. Circular RNAs (circRNAs) have...
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Progress and application of adipose-derived stem cells in the treatment of diabetes and its complications
Diabetes mellitus (DM) is a serious chronic metabolic disease that can lead to many serious complications, such as cardiovascular disease,...
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Mechanisms of β-adrenergic receptors agonists in mediating pro and anti-apoptotic pathways in hyperglycemic Müller cells
BackgroundThe current study aimed to investigate the stimulatory effect of beta-adrenergic receptors (β-ARs) on brain derived neurotropic factor...
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Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy
In our study, we focused on possible effects of supplementation with glucan and vitamin D on total numbers of NK cells in patients with diabetic...
