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The crosstalk between bacteria and host autophagy: host defense or bacteria offense
Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host...
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Sialylation of cell surface glycoconjugates modulates cytosolic galectin-mediated responses upon organelle damage
Sialylation is an important terminal modification of glycoconjugates that mediate diverse functions in physiology and disease. In this review we...
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Peculiarities of the Mesonephros Cell Ultrastructure of the Prussian Carp Carassius gibelio (Cypriniformes, Cyprinidae) under Various Salinity Conditions
Abstract —The mesonephros ultrastructure has been studied for 12 specimens of sexually mature Carassius gibelio Bloch 1782 living in the freshwater...
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Mixta mediterraneensis as a novel and abundant gut symbiont of the allergen-producing domestic mite Blomia tropicalis
Blomia tropicalis is an allergen-producing mite in the human environment in tropical regions. The microbiome of B. tropicalis was described using the...
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DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency
BackgroundGBA1 mutations are the most common genetic risk factor for development of Parkinson’s disease (PD). The loss of catalytic activity in GBA1,...
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Targeting of phagolysosomes containing conidia of the fungus Aspergillus fumigatus with polymeric particles
AbstractConidia of the airborne human-pathogenic fungus Aspergillus fumigatus are inhaled by humans. In the lung, they are phagocytosed by alveolar...
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Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis
Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor microenvironment (TME), play multifaceted roles in cancer progression...
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Chronic effects induced by zinc oxide nanoparticles against larvae of the northern house mosquito Culex pipiens (Diptera: Culicidae)
It is estimated that up to a million person are subject to death every year from mosquito-borne diseases. To avoid the epidemic situations arising...
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Genome-wide analysis of acid tolerance genes of Enterococcus faecalis with RNA-seq and Tn-seq
Enterococcus faecalis , a formidable nosocomial and community-acquired opportunistic pathogen, can persist a wide range of extreme environments,...
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Functional Analysis of Genes in Mycobacterium tuberculosis Action Against Autophagosome–Lysosome Fusion
Tuberculosis is a lethal disease that is one of the world's top ten death-associated infections in humans; Mycobacterium tuberculosis causes...
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Functional Diversity of Macropinocytosis
Eukaryotic cells are capable of internalizing different types of cargo by plasma membrane ruffling and forming vesicles in a process known as...
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Measurement of Salmonella enterica Internalization and Vacuole Lysis in Epithelial Cells
Establishment of an intracellular niche within mammalian cells is key to the pathogenesis of the gastrointestinal bacterium, Salmonella enterica...
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Dynamic immune response characteristics of piglets infected with Actinobacillus pleuropneumoniae through omic
Porcine infectious pleuropneumonia is characterized by a high-rate of carriage and mixed infection with other pathogens. The host immune response...
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Autophagy restricts Mycobacterium tuberculosis during acute infection in mice
Whether or not autophagy has a role in defence against Mycobacterium tuberculosis infection remains unresolved. Previously, conditional knockdown of...
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Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves
BackgroundBivalves have independently evolved a variety of symbiotic relationships with chemosynthetic bacteria. These relationships range from endo-...
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P38-DAPK1 axis regulated LC3-associated phagocytosis (LAP) of microglia in an in vitro subarachnoid hemorrhage model
BackgroundThe phagocytosis and homeostasis of microglia play an important role in promoting blood clearance and improving prognosis after...
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Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells
Autophagy is typically activated in cancer cells as a rescue strategy in response to cellular stress (e.g., chemotherapy). Herein, we found that...
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Mechanism of the toxic effects of tetracycline on blood meal digestion in Haemaphysalis longicornis
The extensive utilization of antibiotics in the field of animal husbandry gives rise to various concerns pertaining to the environment and human...
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Coral–algal endosymbiosis characterized using RNAi and single-cell RNA-seq
Corals form an endosymbiotic relationship with the dinoflagellate algae Symbiodiniaceae, but ocean warming can trigger algal loss, coral bleaching...
