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An electrochemiluminescence resonance energy transfer biosensor based on CDs/PAMAM/rGO nanocomposites and Au@Ag2S nanoparticles for PML/RARα fusion gene detection
In recent years, electrochemiluminescence resonance energy transfer (ECL-RET) with low background signal and high specificity has attracted much...
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Ultrasensitive detection of genetic variation based on dual signal amplification assisted by isothermal amplification and cobalt oxyhydroxide nanosheets/quantum dots
PML/RARα fusion gene (P/R) is the characteristic signature genetic variation of acute promyelocytic leukemia (APL). Here, by integrating...
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Droplet digital PCR for quantification of PML-RARα in acute promyelocytic leukemia: a comprehensive comparison with real-time PCR
Real-time quantitative PCR (qPCR) has been widely implemented for molecular testing, but there are still some inherent limitations that hamper its...
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Nanobiosensors: Construction and Diagnosis of Disease
Nanobiosensors, which are advancing daily, are of interest to many researchers and enabled developments in this field. Considering the increasing... -
Stimuli-responsive DNA-based hydrogels for biosensing applications
The base sequences of DNA are endowed with the rich structural and functional information and are available for the precise construction of the 2D...
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Fat-Soluble Vitamins
Vitamins are essential micronutrients that are required in small quantities to perform various activities, ranging from everyday metabolic processes... -
Self-assembling ferritin-dendrimer nanoparticles for targeted delivery of nucleic acids to myeloid leukemia cells
BackgroundIn recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Arc...
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Therapeutic Paradigm Underscoring Glucosinolate Sulforaphane in Chemo- and Radiosensitization of Cancer: Preclinical and Clinical Perspective
Fruits and vegetables harbor innocuous bioactive compounds which after absorption and distribution tend to have an effect on general defense... -
Therapeutic Paradigm Underscoring Glucosinolate Sulforaphane in Chemo- and Radiosensitization of Cancer: Preclinical and Clinical Perspective
Fruits and vegetables harbor innocuous bioactive compounds which after absorption and distribution tend to have an effect on general defense... -
Sequence-specific electrochemical detection of double-strand PCR amplicons of PML/RARα fusion gene in acute promyelocytic leukemia
A novel electrochemical method for the sequence-specific detection of double-stranded polymerase chain reaction (PCR) products of PML/RARα fusion...
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A lipase-based electrochemical biosensor for target DNA
A lipase-based electrochemical biosensor has been fabricated for the quantitative determination of target DNA. It is based on a stem-loop nucleic...
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Sustainable Enzyme Technology for Environment: Biosensors for Monitoring of Pollutants and Toxic Compounds
The recent developments in enzyme technology have raised the interest of researchers toward develo** cost-effective enzyme-based techniques against... -
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
The term “epigenetics” refers to modifications in gene expression caused by heritable, but potentially reversible, changes in DNA methylation and... -
Speciation of arsenic trioxide metabolites in blood cells and plasma of a patient with acute promyelocytic leukemia
Arsenic trioxide (As 2 O 3 ) has been widely accepted as the second-best choice for the treatment of relapsed and refractory acute promyelocytic leukemia...
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Arsenic trioxide and neuroblastoma cytotoxicity
The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge...
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Differentiation response of acute promyelocytic leukemia cells and PML/RARα leukemogenic activity studies by real-time RT-PCR
Acute promyelocytic leukemia (APL) is a human cancer generated by a chromosomal translocation t(15;17) involving the promyelocytic leukemia (PML) and...