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Efficient 2,3-butanediol production from whey powder using metabolically engineered Klebsiella oxytoca
BackgroundWhey is a major pollutant generated by the dairy industry. To decrease environmental pollution caused by the industrial release of whey,...
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Controlled Ring-opening (Co)Polymerization of Renewable Macrolactones by Al-based Catalysts with Different Sidearms
It remains a challenging task to achieve ring-opening (co)polymerization (ROP) of macrolactones. Hence, we synthesized a series of Al -based catalysts...
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In vivo metallophilic self-assembly of a light-activated anticancer drug
Self-assembling molecular drugs combine the easy preparation typical of small-molecule chemotherapy and the tumour-targeting properties of...
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Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau
Tau pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathiesTautauopathies. In most of these...
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Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research
The study of microtubule (MT) dynamics is essential for the understanding of cellular transport, cell polarity, axon formation, and other...
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Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties
Pathological alterations of the neuronal Tau proteinTauprotein are characteristic for many neurodegenerative diseases, called...
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Elucidating the Origin of Regioselectivity in Palladium-Catalyzed Aromatic Fluorination: Mechanistic Investigation and Microkinetic Analysis
Nucleophilic fluorination of aromatic rings can be done via a cross-coupling reaction catalyzed by palladium and biaryl monophosphine ligands such as...
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Enzymatic Synthesis of Polyesters via Ring-Opening Polymerization
An enzyme can act as a powerful catalyst for the production and chemical recycling of green and sustainable polymers via a ring-opening...
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Effective methods for immobilization of non-adherent Pv11 cells while maintaining their desiccation tolerance
Pv11 was derived from embryos of the slee** chironomid Polypedilum vanderplanki , which displays an extreme form of desiccation tolerance known as...
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Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway
Xenogeneic extracellular matrices (xECM) for cell support have emerged as a potential strategy for addressing the scarcity of donor matrices for...
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Electrospun porous carbon nanofibers derived from bio-based phenolic resins as free-standing electrodes for high-performance supercapacitors
Phenolic resins were employed to prepare electrospun porous carbon nanofibers with a high specific surface area as free-standing electrodes for...
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Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds
For many years, unactivated alkyl electrophiles that contain β hydrogens were generally regarded as unsuitable partners for palladium-catalyzed...
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The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells
BackgroundIn hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or...
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Übergangsmetallkatalysierte Kupplungsreaktionen
Übergangsmetalle können schwierige Transformationen effizient katalysieren. Vor allem Pd-Komplexe, aber auch Katalysatoren basierend auf Ni, Cu oder...
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A Human Neurovascular Unit On-a-Chip
Protection of the central nervous system (CNS) and cerebral homeostasis depend upon the blood–brain barrier (BBB) functions and permeability. BBB...
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Transfection, Spinfection, Exofection, and Luciferase Assays for Analysis of CCN Genes Expression Mechanism
Cell communication network factor 2 (CCN2), also known as connective tissue growth factor (CTGF), is protein inducible in response to TGFβ/Smad...
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Facile and Green Synthesis of Pd-Decorated Alginate/ Nanofibrillated Cellulose Aerogel for Simultaneous Dye Degradation, Oil/Water Separation and Oil Collection
Water pollution caused by dyeing wastewater discharge, organic chemical reagent leakage and frequent oil spill incidents has aroused widespread...
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Organic and inorganic antimicrobials incorporated into acrylic resin: antimicrobial efficacy and cytotoxicity: a systematic review
This review aimed to investigate the literature systematically and answer the question “Does the processing method of organic and inorganic agents...
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Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
The utility of inter- and intramolecular Heck arylations in the synthesis of intermediates for the preparation of active pharmaceutical ingredients...
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Thermoplasmonic Scaffold Design for the Modulation of Neural Activity in Three-Dimensional Neuronal Cultures
Neuromodulation has made great strides in recent years, but in vitro studies have been limited to two-dimensional cell cultures, far from in vivo...
