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Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation
Ultraviolet radiation (UVR) predominantly induces UV-signature mutations, C → T and CC → TT base substitutions at dipyrimidine sites, in the cellular...
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Influence of the Aptamer Grafting on its Conformation and its Interaction with Targeted Protein
Aptamers are functional small single-strand oligonucleotides (DNA) that show high affinity to their target molecules such as proteins or small...
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Radiolysis of adenine and its complementary bases in aqueous solutions and clay suspensions
The aim of this work is to establish whether the presence of a solid surface during the radiolysis of complementary nitrogenous bases (adenine,...
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The development of genome editing tools as powerful techniques with versatile applications in biotechnology and medicine: CRISPR/Cas9, ZnF and TALE nucleases, RNA interference, and Cre/loxP
The huge progress in whole genome sequencing (genomic revolution) methods including next generation sequencing (NGS) techniques allows one to obtain...
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Novel adenine/thymine photodimerization channels mapped by PCM/TD-DFT calculations on dApT and TpdA dinucleotides
Despite the biological relevance of AT-rich DNA sequences, the excited state paths associated with the photochemical reactions involving adenine and...
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Safety of Processed Juice and Products
Juices and juice products have become popular beverages among consumers of all ages because they have excellent taste and nutritional qualities....
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Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
Pyridoxal 5’-phosphate (PLP)-dependent enzymes utilize a vitamin B 6 -derived cofactor to perform a myriad of chemical transformations on amino acids...
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Molecular Beacons With and Without Quenchers
Modified nucleic acids have a wide range of applications in many areas of biochemistry. In particular, fluorescence-based nucleic acid systems have...
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i-Motif DNA structures upon electric field exposure: completing the map of induced genetic errors
The architecture of DNA is not exclusively assembled with a sequence of Watson–Crick guanine–cytosine (GC) and adenine–thymine (AT) base pairs. On...
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Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga
G-quadruplexes (G4s) are non-canonical secondary structures that can form in single-stranded DNA and RNA sequences containing multiple guanine...
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Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga
G-quadruplexes (G4s) are non-canonical secondary structures that can form in single-stranded DNA and RNA sequences containing multiple guanine...
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DNA Nanotechnology for Multimodal Synergistic Theranostics
Over the past decade, DNA nanotechnology has developed rapidly due to its unique characteristics, such as excellent biocompatibility, high...
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Studying the excited electronic states of guanine rich DNA quadruples by quantum mechanical methods: main achievements and perspectives
The main insights into the photoactivated dynamics of guanine quadruplexes (G4s) recently provided by quantum mechanical computations are concisely...
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Interfacing DNA nanotechnology and biomimetic photonic complexes: advances and prospects in energy and biomedicine
Self-assembled photonic systems with well-organized spatial arrangement and engineered optical properties can be used as efficient energy materials...
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Carbon Nanotubes and Nucleic Acids
Carbon materials have always held a very important position in materials research owing to their unique chemical structures, physiochemical...
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Microbial Decontamination of Rice Germ Using a Large-Scale Plasma Jet-Pulsed Light-Ultraviolet-C Integrated Treatment System
Integration of plasma and pulsed light or ultraviolet has been investigated for microbial decontamination of foods. However, no studies have reported...
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OGG1 at the Crossroads Between Repair and Transcriptional Regulation
Oxidative DNA modifications are a major challenge to genomic stability. One of the most abundant oxidative DNA base damage is the 8-oxoG, a mutagenic...
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OGG1 at the Crossroads Between Repair and Transcriptional Regulation
Oxidative DNA modifications are a major challenge to genomic stability. One of the most abundant oxidative DNA base damage is the 8-oxoG, a mutagenic...
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Genome-based engineering of ligninolytic enzymes in fungi
BackgroundMany fungi grow as saprobic organisms and obtain nutrients from a wide range of dead organic materials. Among saprobes, fungal species that...
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UV-C Treatment of Apple and Grape Juices by Modified UV-C Reactor Based on Dean Vortex Technology: Microbial, Physicochemical and Sensorial Parameters Evaluation
A laboratory-scale ultraviolet (UV-C) reactor based on Dean vortex technology was designed and tested for its capability to inactivate microorganisms...
